TY  - JOUR
A1  - Gierer, Alfred
T1  - Function of aggregated reticulocyte ribosomes in protein synthesis
N2  - Applying mild methods of preparation, part of the ribosomes of rabbit reticulocytes are found in aggregates (later called polyribosomes) of up to six ribosomal units. Upon treatment with RNA-ase, they desintegrate into single ribosomes. The fast-sedimenting aggregates are found to be more active in protein synthesis in terms of incorporation of radioactive amino acids, whereas the single ribosomes are more receptive to stimulation by the artificial messenger RNA poly-U. The findings indicate that the linkage of ribosomes into aggregates is due to the messenger RNA. They support a tape-reading mechanism of protein synthesis whereby growth of the peptide chain is accompanied by shifting the active site of the ribosome from one coding group of nucleotides of the messenger RNA to the next.
KW  - protein synthesis
KW  - Polyribosomes
KW  - Polysomes
KW  - Reticulocytes
KW  - messenger RNA
Y1  - 2006
UR  - https://edoc.bbaw.de/frontdoor/index/index/docId/159
UR  - https://nbn-resolving.org/urn:nbn:de:kobv:b4360-100730
UR  - http://edoc.bbaw.de/oa/books/reM2apjEnfctQ/PDF/29fMUqxcYCU.pdf
ER  -