TY - UNPD A1 - Gierer, Alfred T1 - Structure and biological function of ribonucleic acid from Tobacco Mosaic Virus N2 - Within the sedimentation diagram of infective RNA preparations isolated from Tobacco Mosaic Virus, undegraded molecules form a sharp peak with a molecular weight corresponding to the total RNA content of the virus particle. Degradation kinetics by ribonuclease is of the linear, single-target type, indicating that the RNA is single-stranded. The intact RNA of a virus particle thus forms one big single-stranded molecule. Quantitative evaluation of the effect degradation by RNA-ase on the infectivity of the RNA shows that the integrity of the entire molecule is required for its biological activity. KW - infectivity KW - TMV KW - RNA KW - single strand Y1 - 2006 UR - https://edoc.bbaw.de/frontdoor/index/index/docId/184 UR - https://nbn-resolving.org/urn:nbn:de:kobv:b4360-1001017 UR - http://edoc.bbaw.de/oa/articles/rePbSUW9jsXYU/PDF/24aF8Y77EwS8s.pdf ER -