TY  - JOUR
A1  - Gierer, Alfred
T1  - Directional cues for growing axons forming the retinotectal projection
N2  - Aside from the increasing, impressive evidence on chemical identification of graded molecules involved, it is the capability of axons for approaching the target position from different aspects in a two-dimensional field which is per se a strong indication for the involvement of gradients. Targeting requires, in the target field, counter-graded effects, either by antagonistic gradients, or by a single gradient in each dimension exerting attractive effects at low, reverting to inhibitory (repulsive) effects at high concentrations. A further requirement for mapping is the modulation of the counter-graded effects by components of the growth cone itself which depends on the origin of the corresponding axon.Transduction and processing of graded signals in the navigating growth cones are proposed to be strongly enhanced by intra-growth-cone pattern formation. The concept also encompasses regulatory and branching processes including the formation of the terminal arbors.
KW  - terminal arbour
KW  - pattern formation
KW  - neurogenesis
KW  - growth cone
KW  - axons
KW  - guidance
KW  - gradients
KW  - retinotectal
KW  - projection
KW  - axonal branching
Y1  - 2006
UR  - https://edoc.bbaw.de/frontdoor/index/index/docId/163
UR  - https://nbn-resolving.org/urn:nbn:de:kobv:b4360-100782
UR  - http://edoc.bbaw.de/oa/articles/reMcGbnMcQdg/PDF/28xA7zWCEUA5Y.pdf
ER  -