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Regeneration of hydra from reaggregated cells

  • Aggregates of previously isolated cells of Hydra are capable, under suitable solvant conditions, of regeneration forming complete animals. In a first stage, ecto- and endodermal cells sort out, producing the bilayered hollow structure characteristic of Hydra tissue; thereafter, heads are formed (even if the original cell preparation contained no head cells), eventually leading to the separation of normal animals with head, body column and foot. Hydra appears to be the highest type of organism that allows for regeneration of the entire structure from random cell aggregates. The system is particularly useful for studying cell interactions, tissue polarity, pattern formation, and cell differentiation.

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Author:Alfred Gierer, S. Berking, H. Bode, C. N. David, K. Flick, G. Hansmann, H. Schaller, E. Trenkner
Document Type:Article
Date of Publication (online):2006/11/07
Release Date:2006/11/07
Tag:cell aggregates; head formation; hydra; polarity; regeneration; sorting out
Source:Nature / New biology ; 239, S. 98-101
Institutes:BBAW / Veröffentlichungen von Akademiemitgliedern
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 50 Naturwissenschaften / 500 Naturwissenschaften und Mathematik