570 Biowissenschaften; Biologie
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Introduction
(2019)
When thinking about the historic landscape gardens of the Berlin-Brandenburg region we tend to focus automatically on the royal gardens that Peter Joseph Lenné originally included in his beautification plan for the Potsdam area that are now a UNESCO World Heritage Site. There is good reason for this focus. The complex of Sanssouci, Charlottenhof, Neuer Garten, Babelsberg, Glienicke, and Pfaueninsel constitutes an extraordinarily beautiful panorama. But from a broader perspective the unique character of these gardens can be seen to have informed the garden landscape of all of Berlin in a series of social transformations that occurred during the course of industrialisation in the nineteenth century. For this purpose it is useful to focus on the role of steam power. By no means, however, did the significance of steam power (or the lack of it) end with its utilitarian function, for it informed the aesthetic character of landscape gardens, too. And this character changed with the historical transformations that associated different sorts of gardens with people in different social strata. I will schematise three such »classes« of people and gardens.
Dealing with the Consequences of Climate Change in Historic Parks and Gardens in the United Kingdom
(2019)
Given that long term climate change is recognised as having an ›impact upon all aspects of daily life, not least the survival of heritage assets‹ there is a need to consider all aspects of heritage in the United Kingdom (UK). In order to provide an international context for the German situation this paper looks specifically at adaptation measures that have developed within the main British conservation and horticultural organisations, Historic England, the National Trust and the Royal Horticultural Society. It does this by providing some cultural context for the present policies. It then looks at how the climate is expected to change by the end of this century. It identifies the main challenges, and then reviews the responses by way of adaptation and mitigation.
Historic parks and gardens survive in many places with some sites still in use but others abandoned long ago and now given over to other purposes. Accurate repair and reliable reconstruction depend upon archaeological information which is particularly vulnerable to the effects of climate change. The impairment and loss of such detail threaten historical integrity. This means that we must monitor changes and develop suitable mitigation.
This paper presents the Bogoroditsk (Tula Region in Russia) Park’s history of origin in the 18th century, its subsequent functioning and degrading. Special attention is paid to the contribution of A. T. Bolotov serving as the supervisor of Bogoroditsk Volost in the 1770s–1790s. In conclusion, the contemporary state of Bogoroditsk Park and its water-supply facilities that is worrying the experts is described.
The creation of a representation official park of nationwide scale and importance is hedged about with a lot of difficulties. It is supposed to be a paragon of beauty and utility while also being an epoch’s monument remaining in place for long decades or centuries. The paper analyses the balance between the beauty and sustainability in the conception and the actual life of eight parks in the realm of Russian culture (Russian Empire, Soviet Union, Russian Federation). That said, one of them (House of Bezborodko) represents an unconsummated project, but one that is typical of its epoch.
Single-cell analyses comprise a multitude of analytical methods that share a common feature, namely the focus on individual cells. This is in contrast to previous methods that provided summarized data for cell clusters, groups of cells, tissues and organs. The new field offers huge potential not only for basic research, but also for medical and biotechnological applications, as it opens up new levels in the context-related and personal interpretation of biological interconnections. This brochure on single-cell analysis provides an overview on the new possibilities from the viewpoint of developmental biology, biomedicine and bioinformatics, but also addresses possible social im-plications and consequences.
The short paper introduces the concept of possible branches of double-stranded DNA (later sometimes called palindromes): Certain sequences of nucleotides may be followed, after a short unpaired stretch, by a complementary sequence in reversed order, such that each DNA strand can fold back on itself, and the DNA assumes a cruciform or tree-like structure. This is postulated to interact with regulatory proteins.
New, precise genetic engineering methods for genome alteration in living cells, which can be classed together under the generic heading “genome surgery”,are currently sparking a revolution in biomedical research. The Interdisciplinary Research Group Gene Technology Report is, in principle, in favour of research on these promising new methods for the medical sector. However, for the time being, it has clearly spoken out against gene surgery experiments on the human germ line, which could also enter the realm of possibility thanks to these methods.The research group, therefore, supports the call, which has already been discussed at length in scientific and public circles, for a moratorium for germ line experiments. The period of the moratorium should be used to debate the experimental,
ethical and legal aspects of germ line therapy in an open, transparent
and critical manner with a view to more clearly defining the opportunities and
risks of these technologies for man and nature, and to elaborating recommendations for future regulations. The goal of this analysis is to promote a discourse of this kind.
The introductory personal remarks refer to my motivations for choosing research projects, and for moving from physics to molecular biology and then to development, with Hydra as a model system. Historically, Trembley’s discovery of Hydra regeneration in 1744 was the begin¬ning of developmental biology as we understand it, with passionate debates about preformation versus de novo generation, mechanisms versus organisms. In fact, seemingly conflicting bottom-up and top-down concepts are both required in combination to understand development. In modern terms, this means analysing the molecules involved, as well as searching for physical principles underlying development within systems of molecules, cells and tissues. During the last decade, molecular biology has provided surprising and impressive evidence that the same types of mol¬ecules and molecular systems are involved in pattern formation in a wide range of organisms, including coelenterates like Hydra, and thus appear to have been “invented” early in evolution. Likewise, the features of certain systems, especially those of developmental regulation, are found in many different organisms. This includes the generation of spatial structures by the interplay of self-enhancing activation and “lateral” inhibitory effects of wider range, which is a main topic of my essay. Hydra regeneration is a particularly clear model for the formation of defined patterns within initially near-uniform tissues. In conclusion, this essay emphasizes the analysis of development in terms of physical laws, including the application of mathematics, and insists that Hydra was, and will continue to be, a rewarding model for understanding general features of embryogenesis and regeneration.
The future of biological diversity in a crowded world (Ernst Mayr Lecture on 29th October 2002)
(2006)
Introduction : The Grants, Dreaming Darwin's Dream ; (Ernst Mayr Lecture am 4. November 2004)
(2006)
Biological evolution and technological innovation, while differing in many respects, also share common features. In particular, the implementation of a new technology in the market is analogous to the spreading of a new genetic trait in a population. Technological innovation may occur either through the accumulation of quantitative changes, as in the development of the ocean clipper, or it may be initiated by a new combination of features or subsystems, as in the case of steamships. Other examples of the latter type are electric networks that combine the generation, distribution, and use of electricity, and containerized transportation that combines standardized containers, logistics, and ships. Biological evolution proceeds, phenotypically, in many small steps, but at the genetic level novel features may arise not only through the accumulation of many small, common mutational changes, but also when distinct, relatively rare genetic changes are followed by many further mutations. New evolutionary directions may be initiated by, in particular, some rare combinations of regulatory sections within the genome. The combinatorial type of mechanism may not be a logical prerequisite for biological innovation, but it can be efficient, especially when novel features arise out of already highly developed systems. Such is the case with the evolution of general, widely applicable capabilities of the human brain. Hypothetical examples include the evolution of strategic thought, which encompasses multiple self-representations, cognition-based empathy, meta-levels of abstraction, and symbolic language. These capabilities of biologically modern man may have been initiated, perhaps some 150 000 years ago, by one or few accidental but distinct combinations of modules and subroutines of gene regulation which are involved in the generation of the neural network in the cerebral cortex. This hypothesis concurs with current insights into the molecular biology of the combinatorial and hierarchical facets of gene regulation that underlie brain development. A theory of innovation encompassing technological as well as biological development cannot per se dictate alternative explanations of biological evolution, but it may help in adding weight and directing attention to notions outside the mainstream, such as the hypothesis that few distinct genetic changes were crucial for the evolution of modern man.
The topic of this article is the relation between bottom-up and top-down, reductionist and “holistic” approaches to the solution of basic biological problems. While there is no doubt that the laws of physics apply to all events in space and time, including the domains of life, understanding biology depends not only on elucidating the role of the molecules involved, but, to an increasing extent, on systems theoretical approaches in diverse fields of the life sciences. Examples discussed in this article are the generation of spatial patterns in development by the interplay of autocatalysis and lateral inhibition; the evolution of integrating capabilities of the human brain, such as cognition-based empathy; and both neurobiological and epistemological aspects of scientific theories of consciousness and the mind.