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In 20 articles experts from research, politics and research management discuss current challenges and future advancements of European research infrastructures for the humanities and social sciences, particularly in view of the funding scheme Horizon 2020 and the ESRFI Roadmap update. Starting with an overview of SSH infrastructures it elaborates on four specific areas that increasingly demand a pan-European approach. Drawing from the SSH infrastructure projects´ experience, it then (re-) defines the requirements and potential for next generation infrastructure projects. They highlight the developments and problems they anticipate, focussing in particular on advancing digitalisation in the SSH. The book draws together the insights gained at a conference of the same name, “Facing the Future”, held in Berlin in November 2013. The conference was attended by 70 experts from 19 European countries who met to discuss the new challenges posed by the increasing necessity of integrating digital research tools into everyday working life. It was organised by the European Strategy Forum on Research Infrastructures (ESFRI), the federation of All European Academies (ALLEA), the Union of the German Academies of Sciences and Humanities, and the German Data Forum. It took place as part of a project financed by the German Federal Ministry of Education and Research (BMBF) entitled Survey and Analysis of Basic Research in the Social Sciences and Humanities in Europe (SASSH).
We expose analogies between turbulence in a fluid heated from below (Rayleigh-Bénard (RB) flow) and shear flows: The unifying theory for RB flow (S.Grossmann and D.Lohse, J.Fluid Mech. 407, 27-56 (2000) and subsequent refinements) can be extended to the flow between rotating cylinders (Taylor-Couette flow) and pipe flow. We identify wind dissipation rates and momentum fluxes that are analogous to the dissipation rate and heat flux in RB flow. The proposed unifying description for the three cases is consistent with the experimental data.
For a fistful of blogs: Discovery and comparative benchmarking of republishable German content
(2014)
We introduce two corpora gathered on the web and related to computer-mediated communication: blog posts and blog comments. In order to build such corpora, we addressed following issues: website discovery and crawling, content extraction constraints, and text quality assessment. The blogs were manually classified as to their license and content type. Our results show that it is possible to find blogs in German under Creative Commons license, and that it is possible to perform text extraction and linguistic annotation efficiently enough to allow for a comparison with more traditional text types such as newspaper corpora and subtitles. The comparison gives insights on distributional properties of the processed web texts on token and type level. For example, quantitative analysis reveals that blog posts are close to written language, while comments are slightly closer to spoken language.
Stephen Jay Gould wrote recently that “when Church began to paint his great canvases, Alexander von Humboldt may well have been the world’s most famous and influential intellectual.” Humboldt’s influence in the case of the landscape artist Church is especially interesting. If we examine the precise relationship between the German explorer and his American admirer, we gain an insight into how Humboldt transformed Church’s life and signaled a new phase in the career of the artist. Church retraced Humboldt’s travels in Ecuador and in Mexico. If we compare the texts available to Church and the comparison of Church’s paintings and the texts and images of Humboldt’s works we can arrive at new perspectives on Humboldt’s extraordinary influence on American landscape painting in the nineteenth century.
From exclusion to inclusion : improving clinical research in vulnerable populations ; memorandum
(2014)
Therapeutic care for vulnerable populations – meaning patient groups such as underage children and the mentally ill that have limited or no capacity for giving informed consent – is severely lacking. Thus, for example, a great portion of pharmaceuticals used in the treatment of children and youth have not been specifically designed for these groups, which often results in side effects that are disproportionate to those associated with such medicines when used by adults. Moreover, vulnerable populations are at times faced with having no therapies at all for some of their ailments, such that children and dementia sufferers, for example, are often considered to be “therapeutic orphans”. It is therefore urgent that clinical research be carried out among vulnerable populations in order to improve their therapeutic possibilities. The Clinical Research on Vulnerable Populations Research Group – a cooperative effort between the Berlin-Brandenburg Academy of Sciences and Humanities (Berlin, Germany) and the European Academy of Technology Assessment (Bad Neuenahr, Germany) – has set itself the task of analyzing the state of clinical research on vulnerable populations so as to be able to develop suggestions for improving future research of this kind. The results of this work are presented in the following memorandum, which seeks to portray the state-of-the-art in this domain while also assessing the strengths and weaknesses of contemporary ethical and medical perspectives related to it. The memorandum is primarily oriented towards those in the relevant scientific disciplines who can benefit from obtaining an informed consensus regarding the current state of the discussions taking place around this topic.
Applying mild methods of preparation, part of the ribosomes of rabbit reticulocytes are found in aggregates (later called polyribosomes) of up to six ribosomal units. Upon treatment with RNA-ase, they desintegrate into single ribosomes. The fast-sedimenting aggregates are found to be more active in protein synthesis in terms of incorporation of radioactive amino acids, whereas the single ribosomes are more receptive to stimulation by the artificial messenger RNA poly-U. The findings indicate that the linkage of ribosomes into aggregates is due to the messenger RNA. They support a tape-reading mechanism of protein synthesis whereby growth of the peptide chain is accompanied by shifting the active site of the ribosome from one coding group of nucleotides of the messenger RNA to the next.