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- Akademienvorhaben Census of Antique Works of Art and Architecture Known in the Renaissance (14)
- Berlin-Brandenburgische Akademie der Wissenschaften (14)
- Veröffentlichungen von Akademiemitgliedern (13)
- Interdisziplinäre Arbeitsgruppe Gegenworte - Hefte für den Disput über Wissen (8)
- Akademienvorhaben Alexander-von-Humboldt-Forschung (7)
- Akademienvorhaben Altägyptisches Wörterbuch (1)
- Interdisziplinäre Arbeitsgruppe Sprache des Rechts, Vermitteln, Verstehen, Verwechseln (1)
The short paper introduces the concept of possible branches of double-stranded DNA (later sometimes called palindromes): Certain sequences of nucleotides may be followed, after a short unpaired stretch, by a complementary sequence in reversed order, such that each DNA strand can fold back on itself, and the DNA assumes a cruciform or tree-like structure. This is postulated to interact with regulatory proteins.
Mind, Matter and Mathematics
(2008)
Among mass digitization methods, double-keying is considered to be the one with the lowest error rate. This method requires two independent transcriptions of a text by two different operators. It is particularly well suited to historical texts, which often exhibit deficiencies like poor master copies or other difficulties such as spelling variation or complex text structures. Providers of data entry services using the double-keying method generally advertise very high accuracy rates (around 99.95% to 99.98%). These advertised percentages are generally estimated on the basis of small samples, and little if anything is said about either the actual amount of text or the text genres which have been proofread, about error types, proofreaders, etc. In order to obtain significant data on this problem it is necessary to analyze a large amount of text representing a balanced sample of different text types, to distinguish the structural XML/TEI level from the typographical level, and to differentiate between various types of errors which may originate from different sources and may not be equally severe. This paper presents an extensive and complex approach to the analysis and correction of double-keying errors which has been applied by the DFG-funded project “Deutsches Textarchiv” (German Text Archive, hereafter DTA) in order to evaluate and preferably to increase the transcription and annotation accuracy of double-keyed DTA texts. Statistical analyses of the results gained from proofreading a large quantity of text are presented, which verify the common accuracy rates for the double-keying method.
Introduction : The Grants, Dreaming Darwin's Dream ; (Ernst Mayr Lecture am 4. November 2004)
(2006)
Biological evolution and technological innovation, while differing in many respects, also share common features. In particular, the implementation of a new technology in the market is analogous to the spreading of a new genetic trait in a population. Technological innovation may occur either through the accumulation of quantitative changes, as in the development of the ocean clipper, or it may be initiated by a new combination of features or subsystems, as in the case of steamships. Other examples of the latter type are electric networks that combine the generation, distribution, and use of electricity, and containerized transportation that combines standardized containers, logistics, and ships. Biological evolution proceeds, phenotypically, in many small steps, but at the genetic level novel features may arise not only through the accumulation of many small, common mutational changes, but also when distinct, relatively rare genetic changes are followed by many further mutations. New evolutionary directions may be initiated by, in particular, some rare combinations of regulatory sections within the genome. The combinatorial type of mechanism may not be a logical prerequisite for biological innovation, but it can be efficient, especially when novel features arise out of already highly developed systems. Such is the case with the evolution of general, widely applicable capabilities of the human brain. Hypothetical examples include the evolution of strategic thought, which encompasses multiple self-representations, cognition-based empathy, meta-levels of abstraction, and symbolic language. These capabilities of biologically modern man may have been initiated, perhaps some 150 000 years ago, by one or few accidental but distinct combinations of modules and subroutines of gene regulation which are involved in the generation of the neural network in the cerebral cortex. This hypothesis concurs with current insights into the molecular biology of the combinatorial and hierarchical facets of gene regulation that underlie brain development. A theory of innovation encompassing technological as well as biological development cannot per se dictate alternative explanations of biological evolution, but it may help in adding weight and directing attention to notions outside the mainstream, such as the hypothesis that few distinct genetic changes were crucial for the evolution of modern man.
Modern science, based on the laws of physics, claims validity for all events in space and time. However, it also reveals its own limitations, such as the indeterminacy of quantum physics, the limits of decidability, and, presumably, limits of decodability of the mind-brain relationship. At the philosophical level, these intrinsic limitations allow for different interpretations of the relation between human cognition and the natural order. In particular, modern science may be logically consistent with religious as well as agnostic views of humans and the universe. These points are exemplified through the transcript of a discussion between Kurt Gödel and Rudolf Carnap that took place in 1940. Gödel, discoverer of mathematical undecidability, took a proreligious view; Carnap, one of the founders of analytical philosophy, an antireligious view. By the time of the discussion, Carnap had liberalized his ideas on theoretical concepts of science: he believed that observational terms do not suffice for an exhaustive definition of theoretical concepts. Then, responded Gödel, one should formulate a theory or metatheory that is consistent with scientific rationality, yet also encompasses theology. Carnap considered such theories unproductive. The controversy remained unresolved, but its emphasis shifted from rationality to wisdom, not only in the Gödel-Carnap discussion but also in our time.
An der Sprache des Rechts wird Kritik geübt, seit die Aufklärung die Verständlichkeit der Gesetze zu ihrem Anliegen gemacht hat. Mit den großen Kodifikationen des Rechts im ausgehenden 19. Jahrhundert hat die Kritik am angeblich schlechten, unverständlichen Juristendeutsch eine besondere demokratietheoretische Legitimation bekommen. Diese Sprachkritik sucht seit den siebziger Jahren vermehrt bei der Linguistik Rat, wie denn eine bessere Allgemeinverständlichkeit von Rechtstexten verwirklicht werden könnte. Der Band versammelt systematisch aufeinander bezogene Beiträge ausgewiesener Linguisten, Juristen und Schriftsteller zur Problematik des Verständnisses juristischer Sprache, zur Methodik empirischer Verständlichkeitsmessung und zu den Möglichkeiten transdisziplinärer Kooperation zwischen Rechts- und Sprachwissenschaftlern.
Applying mild methods of preparation, part of the ribosomes of rabbit reticulocytes are found in aggregates (later called polyribosomes) of up to six ribosomal units. Upon treatment with RNA-ase, they desintegrate into single ribosomes. The fast-sedimenting aggregates are found to be more active in protein synthesis in terms of incorporation of radioactive amino acids, whereas the single ribosomes are more receptive to stimulation by the artificial messenger RNA poly-U. The findings indicate that the linkage of ribosomes into aggregates is due to the messenger RNA. They support a tape-reading mechanism of protein synthesis whereby growth of the peptide chain is accompanied by shifting the active site of the ribosome from one coding group of nucleotides of the messenger RNA to the next.
Stephen Jay Gould wrote recently that “when Church began to paint his great canvases, Alexander von Humboldt may well have been the world’s most famous and influential intellectual.” Humboldt’s influence in the case of the landscape artist Church is especially interesting. If we examine the precise relationship between the German explorer and his American admirer, we gain an insight into how Humboldt transformed Church’s life and signaled a new phase in the career of the artist. Church retraced Humboldt’s travels in Ecuador and in Mexico. If we compare the texts available to Church and the comparison of Church’s paintings and the texts and images of Humboldt’s works we can arrive at new perspectives on Humboldt’s extraordinary influence on American landscape painting in the nineteenth century.