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Applying mild methods of preparation, part of the ribosomes of rabbit reticulocytes are found in aggregates (later called polyribosomes) of up to six ribosomal units. Upon treatment with RNA-ase, they desintegrate into single ribosomes. The fast-sedimenting aggregates are found to be more active in protein synthesis in terms of incorporation of radioactive amino acids, whereas the single ribosomes are more receptive to stimulation by the artificial messenger RNA poly-U. The findings indicate that the linkage of ribosomes into aggregates is due to the messenger RNA. They support a tape-reading mechanism of protein synthesis whereby growth of the peptide chain is accompanied by shifting the active site of the ribosome from one coding group of nucleotides of the messenger RNA to the next.
Global climate change and aspects of regional climate change in the Berlin-Brandenburg region
(2011)
To obtain an estimate of the average temperature of the northern hemisphere during the last 1200 years, proxy data have been merged with instrumental recordings. These instrumental measurements are, with a few exceptions, only available for the recent 150 years. In the city of Berlin the temperature has been recorded since as early as 1701. However, during the first 150 years the measurements were problematic as location, measurement procedure and instruments changed frequently and without proper documentation. From 1847 onwards observations became more reliable once the Royal Prussian Meteorological Institute had been established. For the last 100 years temperature and precipitation measurements have been performed in parallel at Berlin-Dahlem and Potsdam. The datasets recorded in the city of Berlin and in Berlin-Dahlem have been merged to obtain a record of more than 300 years. It indicates that the temperature of Berlin has risen by 1.04°C during the last 100 years after correcting for the urbanisation effect. In the same period, the total number of frost days has significantly decreased by almost 17 days, and the number of summer days has significantly increased by about 12 days. Annual mean precipitation has hardly changed (decrease less than 0.2 %) during the last century. However, rainfall has decreased by about 4 % in summer and increased by 3 % in winter. All precipitation changes are below the 95 % ignificance level. Model projections indicate that warming will continue which means that Berlin-Brandenburg will experience a temperature rise of about 3-3.5°C by the end of this century for the IPCC scenario A1B. For the same scenario precipitation is expected to increase by 10-20 % in winter and to decrease by 10-30 % in summer: The seasonal precipitation changes compensate each other resulting in an almost unchanged annual mean.
An der Sprache des Rechts wird Kritik geübt, seit die Aufklärung die Verständlichkeit der Gesetze zu ihrem Anliegen gemacht hat. Mit den großen Kodifikationen des Rechts im ausgehenden 19. Jahrhundert hat die Kritik am angeblich schlechten, unverständlichen Juristendeutsch eine besondere demokratietheoretische Legitimation bekommen. Diese Sprachkritik sucht seit den siebziger Jahren vermehrt bei der Linguistik Rat, wie denn eine bessere Allgemeinverständlichkeit von Rechtstexten verwirklicht werden könnte. Der Band versammelt systematisch aufeinander bezogene Beiträge ausgewiesener Linguisten, Juristen und Schriftsteller zur Problematik des Verständnisses juristischer Sprache, zur Methodik empirischer Verständlichkeitsmessung und zu den Möglichkeiten transdisziplinärer Kooperation zwischen Rechts- und Sprachwissenschaftlern.
Modern science, based on the laws of physics, claims validity for all events in space and time. However, it also reveals its own limitations, such as the indeterminacy of quantum physics, the limits of decidability, and, presumably, limits of decodability of the mind-brain relationship. At the philosophical level, these intrinsic limitations allow for different interpretations of the relation between human cognition and the natural order. In particular, modern science may be logically consistent with religious as well as agnostic views of humans and the universe. These points are exemplified through the transcript of a discussion between Kurt Gödel and Rudolf Carnap that took place in 1940. Gödel, discoverer of mathematical undecidability, took a proreligious view; Carnap, one of the founders of analytical philosophy, an antireligious view. By the time of the discussion, Carnap had liberalized his ideas on theoretical concepts of science: he believed that observational terms do not suffice for an exhaustive definition of theoretical concepts. Then, responded Gödel, one should formulate a theory or metatheory that is consistent with scientific rationality, yet also encompasses theology. Carnap considered such theories unproductive. The controversy remained unresolved, but its emphasis shifted from rationality to wisdom, not only in the Gödel-Carnap discussion but also in our time.
Since humans are preferentially settling in flood plains they often influence freshwater systems intensely. The first signs of anthropogenic impacts on surface waters in the Berlin-Brandenburg region are approximately 3000 years old. Considering the multiple and intense human uses of surface waters in this region, we analysed when, how and to which extent regional rivers and streams became impacted by dams, water mills and fish weirs resulting in changes in morphology, hydrology and ecological functioning. We hypothesise that the development and growth of cities in this region necessitated (1) efficient navigability of rivers linking them, (2) efficient use of hydropower resources for mills, and (3) significant pollution of surface waters especially with the beginning of industrial development. We analyse these hypotheses by means of three regional examples and delineate the effects of human uses on selected surface water bodies. Understanding the effects of these historic modifications of surface water supports the identification of options for a sustainable use of surface waters that are currently still subjected to multiple uses but face a significant decrease in discharge due to climate change.
The FEW is a huge dictionary when we consider the sheer mass of data (25 volumes, 16000 pages) and its exhaustive aims. It has indeed the purpose of registering and etymologizing the whole lexicon, not only of French, but also of earlier stages of the language and of Occitan; of every Gallo-romance dialect; of every technical or professional genre; of every language register, including slang. Summing up, the FEW aims to include and describe every single lexical unit which exists or has existed in the territory of ancient Gaul. The sheer size of this undertaking means two things, which directly influence the digitalisation of the dictionary: Firstly, there is a a huge amount of data; secondly, the presentation and organization of the data is exceedingly complex. The reasons for digitalising the FEW are the easy searches for units, and the carrying out of searches using criteria that are not possible to use with the printed version. However, the fulfillment of these purposes includes some risks, and potentially the cutting of some corners, especially the temptation of renouncing reading.
Biological evolution and technological innovation, while differing in many respects, also share common features. In particular, the implementation of a new technology in the market is analogous to the spreading of a new genetic trait in a population. Technological innovation may occur either through the accumulation of quantitative changes, as in the development of the ocean clipper, or it may be initiated by a new combination of features or subsystems, as in the case of steamships. Other examples of the latter type are electric networks that combine the generation, distribution, and use of electricity, and containerized transportation that combines standardized containers, logistics, and ships. Biological evolution proceeds, phenotypically, in many small steps, but at the genetic level novel features may arise not only through the accumulation of many small, common mutational changes, but also when distinct, relatively rare genetic changes are followed by many further mutations. New evolutionary directions may be initiated by, in particular, some rare combinations of regulatory sections within the genome. The combinatorial type of mechanism may not be a logical prerequisite for biological innovation, but it can be efficient, especially when novel features arise out of already highly developed systems. Such is the case with the evolution of general, widely applicable capabilities of the human brain. Hypothetical examples include the evolution of strategic thought, which encompasses multiple self-representations, cognition-based empathy, meta-levels of abstraction, and symbolic language. These capabilities of biologically modern man may have been initiated, perhaps some 150 000 years ago, by one or few accidental but distinct combinations of modules and subroutines of gene regulation which are involved in the generation of the neural network in the cerebral cortex. This hypothesis concurs with current insights into the molecular biology of the combinatorial and hierarchical facets of gene regulation that underlie brain development. A theory of innovation encompassing technological as well as biological development cannot per se dictate alternative explanations of biological evolution, but it may help in adding weight and directing attention to notions outside the mainstream, such as the hypothesis that few distinct genetic changes were crucial for the evolution of modern man.
New, precise genetic engineering methods for genome alteration in living cells, which can be classed together under the generic heading “genome surgery”,are currently sparking a revolution in biomedical research. The Interdisciplinary Research Group Gene Technology Report is, in principle, in favour of research on these promising new methods for the medical sector. However, for the time being, it has clearly spoken out against gene surgery experiments on the human germ line, which could also enter the realm of possibility thanks to these methods.The research group, therefore, supports the call, which has already been discussed at length in scientific and public circles, for a moratorium for germ line experiments. The period of the moratorium should be used to debate the experimental,
ethical and legal aspects of germ line therapy in an open, transparent
and critical manner with a view to more clearly defining the opportunities and
risks of these technologies for man and nature, and to elaborating recommendations for future regulations. The goal of this analysis is to promote a discourse of this kind.
This is the invited evening lecture of the biannual workshop on hydroid development of 1999. Its topic is the role of hydra as a rather puristic model for the de-novo generation of spatial patterns in development, and our work in this field. Emphasis is placed not only on experimental studies, but also on theoretical analysis, because the understanding of spatial order requires a systems approach involving the combination of knowledge on molecules, cells and tissues with mathematical analysis, laws and facts.
Understanding cooperative human behaviour depends on insights into the biological basis of human altruism, as well as into socio-cultural development. In terms of evolutionary theory, kinship and reciprocity are well established as underlying cooperativeness. Reasons will be given suggesting an additional source, the capability of a cognition-based empathy that may have evolved as a by-product of strategic thought. An assessment of the range, the intrinsic limitations, and the conditions for activation of human cooperativeness would profit from a systems approach combining biological and socio-cultural aspects. However, this is not yet the prevailing attitude among contemporary social and biological scientists who often hold prejudiced views of each other's notions. It is therefore worth noticing that the desirable integration of aspects has already been attempted, in remarkable and encouraging ways, in the history of thought on human nature. I will exemplify this with the ideas of the fourteenth century Arab-Muslim historian Ibn Khaldun. He set out to explicate human cooperativeness - "asabiyah" - as having a biological basis in common descent, but being extendable far beyond within social systems, though in a relatively unstable and attenuated fashion. He combined psychological and material factors in a dynamical theory of the rise and decline of political rulership, and related general social phenomena to basic features of human behaviour influenced by kinship, expectation of reciprocity, and empathic emotions.
Upon separation of the protein from the nucleic acid component of tobacco mosaic virus by phenol, using a fast and gentle procedure, the nucleic acid is infective in assays on tobacco leaves. A series of qualitative and quantitative control experiments demonstrates that the biological activity cannot depend on residual proteins in the preparation, but is a property of isolated nucleic acid which is thus the genetic material of the virus.
In the last decade, interaction between scholarly lexicography and the public has grown enormously. While in the old days, the lexicographer and in particular, the scholarly lexicographer, had a tendency to describe the lexicon from an ivory tower, in a way that was for the general public rather unaccessible, a change has been evident for some time now. Interaction with the general public is now more and more appreciated and is even being stimulated within the lexicographic community. This holds too for the Algemeen Nederlands Woordenboek (ANW), a project of the Institute for Dutch Lexicology in Leiden. The ANW is an online scholarly dictionary of contemporary Dutch. In its periodization it is the successor of the Woordenboek der Nederlandsche Taal (WNT), which was completed in 2001 and covers the vocabulary of the Netherlands and Flanders up to around 1976. The editorial staff of the ANW would like to create a dictionary that is suitable for different audiences, ranging from language professionals and other academics to pupils, students and language enthusiasts in general. Consequently, interaction with the public is very important to the ANW editorial staff. It is realised in various ways. First, each dictionary article offers users the option to give feedback. Second, the editorial staff uses questions and comments gathered on internet forums, such as Meldpunt Taal (launched in June 2010) and Neo-term. The ANW staff also approaches the public directly through Twitter, with items such as ‘neologism of the week’, facts about spelling and answers to questions about language that have been received. A relatively new initiative is to call upon the public in the search for information for the dictionary, such as synonyms, pictures and the earliest use of words. Language games and word polls are other ways to increase the interest and involvement of the general public in the ANW.
The African European Mediterranean Academies for Science Education (AEMASE) initiative is committed to promoting science outreach to society and to improving the quality and accessibility of science education in schools throughout the eponymous North-South region. To achieve these aims, one of AEMASE’s key activities is implementing IBSE in more schools and supporting the continued professional development of science educators in IBSE methodology and practice. In the long term, the AEMASE partner institutions, which come from all three geographical areas, seek to contribute to the steady development of quality science and innovation systems by focussing on stimulating and supporting the future generations of researchers and innovators. In this context, key AEMASE partner institutions held an international conference on science education in Rome in May 2014, hosted by the venerable Accademia Nazionale dei Lincei. Participants from six continents shared their professional experiences with IBSE and discussed best practices, challenges and future collaboration opportunities. The conference brought together representatives from three crucial areas of expertise: science, education, and policy. The outcomes of this conference are condensed in the report which serves as a testament to the relevance and importance of quality science education for modern societies.