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A reaction to the article „The Lost Archive“, The Wall Street Journal 12.1.2008, page 1 (US edition) http://online.wsj.com/article/SB120008793352784631.html The belief in the myth that old manuscripts should be mysterious and powerful is part and parcel of the age of Modernity. That such expectations were operative in the discussion on the Qumran fragments is still remembered, and more recently the Da Vinci Code, in itself a quite shallow story, sold extremely well. The fact that the Wall Street Journal placed an article on the “lost Bergsträsser-film archive” of Qur’anic manuscripts on its front page on 12th of January seems to be due to the myth of “textual wars” taking place in the world.
The example of Spain illustrates how the production of socio-ecological scales is centred on the social transformation of nature and the construction of socio-ecological and political-ecological scalar gestalts. Concrete geographies, with choreographies of uneven and shifting social power relations, are etched into these ecological, social, political or institutional scalar configurations. These processes are infused with contested and contestable strategies of individuals and social groups, who mobilise spatial scales as part of struggles for control and empowerment, and contest the power geometries of extant scalar gestalts. Needless to say, the mobilisation of scale, the occupation of geographical scale, and the production of scale are central moments in such processes of socio-spatial change. Struggling for the command of scale, or strategizing around excluding particular groups from the performative capabilities of certain scales, shapes social processes, defines relative empowerment and disempowerment and gives rise to very specific socio-spatial relations.
Numerous high-quality primary text sources—in the context of the curation project described here, this means full-text transcriptions (and corresponding image scans) of German works originating from the 15th to the 19th centuries—are scattered among the web or stored remotely. E.g., transcriptions of historical sources are stored locally on degrading recording media and cannot be found, let alone accessed by third parties. Additionally, idiosyncratic, project-specific markup conventions and uncommon, out-of-date or inflexible storage formats often hinder further usage and analysis of the data. Often, textual resources are accompanied by scarce, insufficient or inaccurate bibliographic information, which is only one further reason why valuable resources, even if available on the web, remain undiscovered by and are of little use to the wider research community. The integration of these dispersed primary text sources into the sustainable, web and centres-based research infrastructure of CLARIN-D will be an important step to solve this problem. The Full Paper illustrates an exemplary approach taken by the »Deutsches Textarchiv« (DTA; www.deutschestextarchiv.de) at the Berlin-Brandenburg Academy of Sciences and Humanities (BBAW) to integrate dispersed textual resources and corresponding image scans from various sources into a large historical text corpus of its own and to insert these into the infrastructure of CLARIN-D.
The introductory personal remarks refer to my motivations for choosing research projects, and for moving from physics to molecular biology and then to development, with Hydra as a model system. Historically, Trembley’s discovery of Hydra regeneration in 1744 was the begin¬ning of developmental biology as we understand it, with passionate debates about preformation versus de novo generation, mechanisms versus organisms. In fact, seemingly conflicting bottom-up and top-down concepts are both required in combination to understand development. In modern terms, this means analysing the molecules involved, as well as searching for physical principles underlying development within systems of molecules, cells and tissues. During the last decade, molecular biology has provided surprising and impressive evidence that the same types of mol¬ecules and molecular systems are involved in pattern formation in a wide range of organisms, including coelenterates like Hydra, and thus appear to have been “invented” early in evolution. Likewise, the features of certain systems, especially those of developmental regulation, are found in many different organisms. This includes the generation of spatial structures by the interplay of self-enhancing activation and “lateral” inhibitory effects of wider range, which is a main topic of my essay. Hydra regeneration is a particularly clear model for the formation of defined patterns within initially near-uniform tissues. In conclusion, this essay emphasizes the analysis of development in terms of physical laws, including the application of mathematics, and insists that Hydra was, and will continue to be, a rewarding model for understanding general features of embryogenesis and regeneration.
The current debates on the demographic transformation have been characterised on the one hand by declining birth rates and on the other by increasing life expectancy. Such debates usually focus on the consequences for society, which are frequently described in dark terms. In this booklet, by contrast, you will find analyses and suggestions on how to improve the situation of children and parents to make it easier to realise the desire to have children.
From exclusion to inclusion : improving clinical research in vulnerable populations ; memorandum
(2014)
Therapeutic care for vulnerable populations – meaning patient groups such as underage children and the mentally ill that have limited or no capacity for giving informed consent – is severely lacking. Thus, for example, a great portion of pharmaceuticals used in the treatment of children and youth have not been specifically designed for these groups, which often results in side effects that are disproportionate to those associated with such medicines when used by adults. Moreover, vulnerable populations are at times faced with having no therapies at all for some of their ailments, such that children and dementia sufferers, for example, are often considered to be “therapeutic orphans”. It is therefore urgent that clinical research be carried out among vulnerable populations in order to improve their therapeutic possibilities. The Clinical Research on Vulnerable Populations Research Group – a cooperative effort between the Berlin-Brandenburg Academy of Sciences and Humanities (Berlin, Germany) and the European Academy of Technology Assessment (Bad Neuenahr, Germany) – has set itself the task of analyzing the state of clinical research on vulnerable populations so as to be able to develop suggestions for improving future research of this kind. The results of this work are presented in the following memorandum, which seeks to portray the state-of-the-art in this domain while also assessing the strengths and weaknesses of contemporary ethical and medical perspectives related to it. The memorandum is primarily oriented towards those in the relevant scientific disciplines who can benefit from obtaining an informed consensus regarding the current state of the discussions taking place around this topic.
New, precise genetic engineering methods for genome alteration in living cells, which can be classed together under the generic heading “genome surgery”,are currently sparking a revolution in biomedical research. The Interdisciplinary Research Group Gene Technology Report is, in principle, in favour of research on these promising new methods for the medical sector. However, for the time being, it has clearly spoken out against gene surgery experiments on the human germ line, which could also enter the realm of possibility thanks to these methods.The research group, therefore, supports the call, which has already been discussed at length in scientific and public circles, for a moratorium for germ line experiments. The period of the moratorium should be used to debate the experimental,
ethical and legal aspects of germ line therapy in an open, transparent
and critical manner with a view to more clearly defining the opportunities and
risks of these technologies for man and nature, and to elaborating recommendations for future regulations. The goal of this analysis is to promote a discourse of this kind.