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Numerous high-quality primary text sources—in the context of the curation project described here, this means full-text transcriptions (and corresponding image scans) of German works originating from the 15th to the 19th centuries—are scattered among the web or stored remotely. E.g., transcriptions of historical sources are stored locally on degrading recording media and cannot be found, let alone accessed by third parties. Additionally, idiosyncratic, project-specific markup conventions and uncommon, out-of-date or inflexible storage formats often hinder further usage and analysis of the data. Often, textual resources are accompanied by scarce, insufficient or inaccurate bibliographic information, which is only one further reason why valuable resources, even if available on the web, remain undiscovered by and are of little use to the wider research community. The integration of these dispersed primary text sources into the sustainable, web and centres-based research infrastructure of CLARIN-D will be an important step to solve this problem. The Full Paper illustrates an exemplary approach taken by the »Deutsches Textarchiv« (DTA; www.deutschestextarchiv.de) at the Berlin-Brandenburg Academy of Sciences and Humanities (BBAW) to integrate dispersed textual resources and corresponding image scans from various sources into a large historical text corpus of its own and to insert these into the infrastructure of CLARIN-D.
The introductory personal remarks refer to my motivations for choosing research projects, and for moving from physics to molecular biology and then to development, with Hydra as a model system. Historically, Trembley’s discovery of Hydra regeneration in 1744 was the begin¬ning of developmental biology as we understand it, with passionate debates about preformation versus de novo generation, mechanisms versus organisms. In fact, seemingly conflicting bottom-up and top-down concepts are both required in combination to understand development. In modern terms, this means analysing the molecules involved, as well as searching for physical principles underlying development within systems of molecules, cells and tissues. During the last decade, molecular biology has provided surprising and impressive evidence that the same types of mol¬ecules and molecular systems are involved in pattern formation in a wide range of organisms, including coelenterates like Hydra, and thus appear to have been “invented” early in evolution. Likewise, the features of certain systems, especially those of developmental regulation, are found in many different organisms. This includes the generation of spatial structures by the interplay of self-enhancing activation and “lateral” inhibitory effects of wider range, which is a main topic of my essay. Hydra regeneration is a particularly clear model for the formation of defined patterns within initially near-uniform tissues. In conclusion, this essay emphasizes the analysis of development in terms of physical laws, including the application of mathematics, and insists that Hydra was, and will continue to be, a rewarding model for understanding general features of embryogenesis and regeneration.