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Upon separation of the protein from the nucleic acid component of tobacco mosaic virus by phenol, using a fast and gentle procedure, the nucleic acid is infective in assays on tobacco leaves. A series of qualitative and quantitative control experiments demonstrates that the biological activity cannot depend on residual proteins in the preparation, but is a property of isolated nucleic acid which is thus the genetic material of the virus.
The article summarizes the contents and the structurtal premises of the “Thesaurus Indogermanischer Text- und Sprachmaterialien” (TITUS), focussing on search functions and facilities and questions of the encoding of ancient languages written in various scripts. Examples are taken from Tocharian, Greek, Vedic Sanskrit, and other ancient Indo-European languages covered by TITUS.
An der Sprache des Rechts wird Kritik geübt, seit die Aufklärung die Verständlichkeit der Gesetze zu ihrem Anliegen gemacht hat. Mit den großen Kodifikationen des Rechts im ausgehenden 19. Jahrhundert hat die Kritik am angeblich schlechten, unverständlichen Juristendeutsch eine besondere demokratietheoretische Legitimation bekommen. Diese Sprachkritik sucht seit den siebziger Jahren vermehrt bei der Linguistik Rat, wie denn eine bessere Allgemeinverständlichkeit von Rechtstexten verwirklicht werden könnte. Der Band versammelt systematisch aufeinander bezogene Beiträge ausgewiesener Linguisten, Juristen und Schriftsteller zur Problematik des Verständnisses juristischer Sprache, zur Methodik empirischer Verständlichkeitsmessung und zu den Möglichkeiten transdisziplinärer Kooperation zwischen Rechts- und Sprachwissenschaftlern.
The FEW is a huge dictionary when we consider the sheer mass of data (25 volumes, 16000 pages) and its exhaustive aims. It has indeed the purpose of registering and etymologizing the whole lexicon, not only of French, but also of earlier stages of the language and of Occitan; of every Gallo-romance dialect; of every technical or professional genre; of every language register, including slang. Summing up, the FEW aims to include and describe every single lexical unit which exists or has existed in the territory of ancient Gaul. The sheer size of this undertaking means two things, which directly influence the digitalisation of the dictionary: Firstly, there is a a huge amount of data; secondly, the presentation and organization of the data is exceedingly complex. The reasons for digitalising the FEW are the easy searches for units, and the carrying out of searches using criteria that are not possible to use with the printed version. However, the fulfillment of these purposes includes some risks, and potentially the cutting of some corners, especially the temptation of renouncing reading.
Among mass digitization methods, double-keying is considered to be the one with the lowest error rate. This method requires two independent transcriptions of a text by two different operators. It is particularly well suited to historical texts, which often exhibit deficiencies like poor master copies or other difficulties such as spelling variation or complex text structures. Providers of data entry services using the double-keying method generally advertise very high accuracy rates (around 99.95% to 99.98%). These advertised percentages are generally estimated on the basis of small samples, and little if anything is said about either the actual amount of text or the text genres which have been proofread, about error types, proofreaders, etc. In order to obtain significant data on this problem it is necessary to analyze a large amount of text representing a balanced sample of different text types, to distinguish the structural XML/TEI level from the typographical level, and to differentiate between various types of errors which may originate from different sources and may not be equally severe. This paper presents an extensive and complex approach to the analysis and correction of double-keying errors which has been applied by the DFG-funded project “Deutsches Textarchiv” (German Text Archive, hereafter DTA) in order to evaluate and preferably to increase the transcription and annotation accuracy of double-keyed DTA texts. Statistical analyses of the results gained from proofreading a large quantity of text are presented, which verify the common accuracy rates for the double-keying method.
From exclusion to inclusion : improving clinical research in vulnerable populations ; memorandum
(2014)
Therapeutic care for vulnerable populations – meaning patient groups such as underage children and the mentally ill that have limited or no capacity for giving informed consent – is severely lacking. Thus, for example, a great portion of pharmaceuticals used in the treatment of children and youth have not been specifically designed for these groups, which often results in side effects that are disproportionate to those associated with such medicines when used by adults. Moreover, vulnerable populations are at times faced with having no therapies at all for some of their ailments, such that children and dementia sufferers, for example, are often considered to be “therapeutic orphans”. It is therefore urgent that clinical research be carried out among vulnerable populations in order to improve their therapeutic possibilities. The Clinical Research on Vulnerable Populations Research Group – a cooperative effort between the Berlin-Brandenburg Academy of Sciences and Humanities (Berlin, Germany) and the European Academy of Technology Assessment (Bad Neuenahr, Germany) – has set itself the task of analyzing the state of clinical research on vulnerable populations so as to be able to develop suggestions for improving future research of this kind. The results of this work are presented in the following memorandum, which seeks to portray the state-of-the-art in this domain while also assessing the strengths and weaknesses of contemporary ethical and medical perspectives related to it. The memorandum is primarily oriented towards those in the relevant scientific disciplines who can benefit from obtaining an informed consensus regarding the current state of the discussions taking place around this topic.
Over millennia human well-being has benefited from ecosystems, not only through tangible goods, but also through intangible assets known as cultural ecosystem services. Despite growing research over the last decade, cultural services assessment still remains arbitrary and is largely limited to marketable services such as tourism. Evident difficulties in standardizing definitions and measurements have challenged cultural services accounting in decision making processes. However, the imminent formation of the Intergovernmental Platform on Biodiversity and Ecosystem Services offers an opportunity to counterbalance this misrepresentation by establishing a scientific basis for consistently assessing cultural services. In that regard, the current review intends to facilitate discussion investigating the current state of cultural services accounting by offering an appraisal of existing evidence regarding cultural services indicator quality. The current review builds on scientifically recognized frameworks to develop a holistic understanding of how cultural services indicators are conceived within ecosystem services research. Among the measures found, benefit indicators were most frequently used for assessing inspirational, educational and recreational services. A broad variety of methods for accounting cultural services was found, mainly due to the varied aims of the studies. Most of the cultural services indicators were deficient concerning their clarity of definitions, purposes and understanding of the processes to be measured and referring only marginally to tradeoffs and bundles with other services. Only 17% performed multitemporal assessments and 23% used spatially explicit information. It seems that cultural services indicators quality could be greatly enhanced by investing more effort towards involving relevant stakeholders in conceptualization and communication phases, using participatory mapping tools to enhance visibility.