Refine
Year of publication
Document Type
- Part of a Book (61)
- Article (59)
- Working Paper (16)
- Conference Proceeding (12)
- Preprint (12)
- Lecture (10)
- Book (3)
- Report (3)
- Other (2)
Language
- English (178) (remove)
Keywords
- Ökosystem (15)
- Antike (12)
- Klimaänderung (12)
- Region Berlin-Brandenburg (10)
- Wasserhaushalt (10)
- Biowissenschaften (8)
- Korpus <Linguistik> (8)
- Kunstgeschichte (8)
- Denkmalpflege (7)
- Historische Gärten (7)
Has Fulltext
- yes (178)
Institute
- Berlin-Brandenburgische Akademie der Wissenschaften (45)
- Veröffentlichungen von Akademiemitgliedern (25)
- Akademienvorhaben Census of Antique Works of Art and Architecture Known in the Renaissance (14)
- Interdisziplinäre Arbeitsgruppe Globaler Wandel (13)
- Interdisziplinäre Arbeitsgruppe Gegenworte - Hefte für den Disput über Wissen (8)
- Akademienvorhaben Alexander-von-Humboldt-Forschung (7)
- Drittmittelprojekt Ökosystemleistungen (7)
- Interdisziplinäre Arbeitsgruppe Historische Gärten im Klimawandel (7)
- Akademienvorhaben Deutsches Wörterbuch von Jacob Grimm und Wilhelm Grimm (6)
- Akademienvorhaben Strukturen und Transformationen des Wortschatzes der ägyptischen Sprache. Text- und Wissenskultur im alten Ägypten (6)
Der Fachkräftemangel in Mathematik, Informatik, Naturwissenschaften und Technik (MINT) erweist sich immer mehr als Hemmnis für den Hochtechnologiestandort Deutschland. Für eine nachhaltige Sicherung des Fachkräftebedarfs ist eine attraktive MINT-Bildung Voraussetzung. Zudem stellt sich in einer Gesellschaft, die von Natur- und Technikwissenschaften geprägt ist, die Notwendigkeit, allen Menschen ein entsprechendes Grundverständnis zu vermitteln. Wissenschaft und Politik sind gefordert, didaktisch wirksame und für junge Menschen attraktive Konzepte für eine MINT-Bildung zu entwickeln und umzusetzen. Einerseits, um begabte junge Menschen gezielt zu fördern, andererseits,um eine basale MINT-Allgemeinbildung im Schulsystem zu verankern. Der Sammelband fasst die Ergebnisse einer interdisziplinären Arbeitsgruppe der Berlin-Brandenburgischen Akademie der Wissenschaften (BBAW) zusammen und analysiert die Ursachen für den mangelnden Erfolg von MINT-Initiativen in Deutschland und Europa, dokumentiert erfolgreiche Modellprojekte und zeigt Lösungswege für die Bildungs- und Wissenschaftspolitik auf. Ergänzt werden diese Beiträge mit den Erfahrungen engagierter Initiatoren von namhaften Modellprojekten.
In the last decade, interaction between scholarly lexicography and the public has grown enormously. While in the old days, the lexicographer and in particular, the scholarly lexicographer, had a tendency to describe the lexicon from an ivory tower, in a way that was for the general public rather unaccessible, a change has been evident for some time now. Interaction with the general public is now more and more appreciated and is even being stimulated within the lexicographic community. This holds too for the Algemeen Nederlands Woordenboek (ANW), a project of the Institute for Dutch Lexicology in Leiden. The ANW is an online scholarly dictionary of contemporary Dutch. In its periodization it is the successor of the Woordenboek der Nederlandsche Taal (WNT), which was completed in 2001 and covers the vocabulary of the Netherlands and Flanders up to around 1976. The editorial staff of the ANW would like to create a dictionary that is suitable for different audiences, ranging from language professionals and other academics to pupils, students and language enthusiasts in general. Consequently, interaction with the public is very important to the ANW editorial staff. It is realised in various ways. First, each dictionary article offers users the option to give feedback. Second, the editorial staff uses questions and comments gathered on internet forums, such as Meldpunt Taal (launched in June 2010) and Neo-term. The ANW staff also approaches the public directly through Twitter, with items such as ‘neologism of the week’, facts about spelling and answers to questions about language that have been received. A relatively new initiative is to call upon the public in the search for information for the dictionary, such as synonyms, pictures and the earliest use of words. Language games and word polls are other ways to increase the interest and involvement of the general public in the ANW.
In Lower Lusatia, eastern Germany, the changing impacts of lignite coal mining and potential climate change have put the naturally low water yield conditions under pressure. Water resources balances describe the hydrological situation in the region and the need for action due to changing boundary conditions. Extended transfer of flood water from neighbouring catchments is considered inevitable for sustainable regional development and the establishment of a quantitatively and qualitatively selfregulated water system. Using the river basin management system WBalMo®, potential water transfer scenarios to compensate for water deficits resulting from regional and global change are analysed.
The concept of ecosystem services was developed capitalizing on ecological knowledge that ecosystems perform various functions like increasing or retarding water fluxes, cleansing or polluting water, modifying microclimatic conditions, sustaining or impoverishing biological diversity and so on. There is growing body of ecological knowledge that management of agricultural landscape for its structural diversity is becoming the important pillar of the sustainability of rural areas. Programmes of environmental protection in rural areas should aim not only at introduction environmental friendly technologies of cultivation within farm. They should also be concerned with challenge of how to increase the resistance or resilience of the whole landscape against threats. Recognition of non -commodity effects of diversified agricultural landscape formed by introduction into cultivated fields shelterbelts, stretches of meadows, small mid -field water reservoirs and other biogeochemical barriers provide new options to combine societal demands with environment production. Co -adaptation of human activities with landscape services relies on policy that economic processes should be conformed with ecological processes operating in the region which are enhancing landscape capacities for naturalization of pollution, regeneration of wastes, recycling of water recourses as well as increasing resistance or resilience of the whole system to stresses caused by production of goals required by society. Recognition of system multifunctionality helps to achieve that goal. The knowledge on processes underpinning ecosystem services opened new frontiers for management of landscapes' structures towards enhancing their capacities to deliver requested services. Forests and shelterbelts show similar functions in the landscape but network of shelterbelts perform many similar services like forests growing on smaller part of landscape area. According to studies carried out by Research Centre for Agricultural and Forest Environment in Poland the following functions of shelterbelts are similar to those shown by forests when 4 -5% of the landscape area is under the network of shelterbelts: - modify the microclimatic conditions and heat and water balances; - control the water chemistry composition (control of diffuse pollution); - limit water and wind erosion; - protect the biodiversity; - increase the survival of the game animals; - enhance recreational value of the region; - provide wood and other products; - promote aesthetic values of the countryside. In this review the first four functions of agricultural landscape within Turew neighborhood will be presented.
The author’s recently published monograph on Alexander von Humboldt' describes the multiple images of this great cultural icon. The book is a metabiographical study that shows how from the middle of the nineteenth century to the present day Humboldt has served as a nucleus of crystallisation for a variety of successive socio-political ideologies, each producing its own distinctive representation of him. The historiographical implications of this biographical diversity are profound and support current attempts to understand historical scholarship in terms of memory cultures.
Ediarum is an editing environment designed and implemented by TELOTA at the Berlin-Brandenburg Academy of Sciences and Humanities (BBAW, Germany). It is based on two main components: an open-source XML native database (eXistDB) and a widely used commercial XML editor (Oxygen XML editor).
The aim of ediarum is to facilitate the task of encoding texts in TEI format, to store the resulting XML files in eXistDB and to enable collaboration and sharing amongst the members of a team. The central framework of this environment --known as ediarum.BASE.edit-- allows the editor to hide the XML tags and use a number of functions through a toolbar and a menu. In other words, the ediarum.BASE.edit's interface increases the usability of the XML editor and speeds up the encoding process and can be adapted to each project's needs. However, this framework is only available in German language. In other words, the code and the language interface are only accessible for and usable by German-speaking users.
While the original goal of TELOTA was to “bridge the gap” between the markup and the editor (Dumont and Fechner, 2015), the interface language creates a barrier for encoders who do not work in German and impedes potential collaborations with other institutions. In order to break this usability and accessibility barrier, in 2020 Proyecto Humboldt Digital (ProHD), a cooperation project between the BBAW and the Oficina del Historiador de la Ciudad de la Habana (Cuba), engaged with an adaptation process involving the internationalization of the software (developing features and code that are independent of language or locale) and the localization in the Spanish locale (creating resource files containing translations). As a result of this process, the project has developed a localization of ediarum.BASE.edit called ediarum.PROHD.edit that can be downloaded on Github.
This paper aims to present ediarum.PROHD.edit and to reflect on the most important challenges encountered during the software localization. After reviewing what “localization” means in Translation Studies (Pym, 2016; Jiménez Crespo, 2016), I will discuss the process of internationalization of the software (mostly variables written in ediarum's default functions), the localization itself (the translation of terms and descriptions displayed in the interface) and some testing undertaken with the Cuban team of Proyecto Humboldt Digital.
New, precise genetic engineering methods for genome alteration in living cells, which can be classed together under the generic heading “genome surgery”,are currently sparking a revolution in biomedical research. The Interdisciplinary Research Group Gene Technology Report is, in principle, in favour of research on these promising new methods for the medical sector. However, for the time being, it has clearly spoken out against gene surgery experiments on the human germ line, which could also enter the realm of possibility thanks to these methods.The research group, therefore, supports the call, which has already been discussed at length in scientific and public circles, for a moratorium for germ line experiments. The period of the moratorium should be used to debate the experimental,
ethical and legal aspects of germ line therapy in an open, transparent
and critical manner with a view to more clearly defining the opportunities and
risks of these technologies for man and nature, and to elaborating recommendations for future regulations. The goal of this analysis is to promote a discourse of this kind.
Research in Silicon Valley
(1998)
The article informs about historical developments and recent problems in the former wetlands of the Oderbruch, which has been cultivated for agricultural use for 300 years, and in the fen region of the Rhin-Havel-Luch. The periodically inundated floodplains of Oderbruch are characterised by rich-in-clay sedimentation soils, while Rhin-Havel-Luch is a year-round wet fen region with peat soils. In both areas land use necessarily requires an adequate regional water management, employing measures and system solutions for river training, dike construction, drainage and soil cultivation. Options for action and adaptation strategies for the next 20 to 40 years, based on many years of own analyses and case studies, are presented and discussed. The article also considers an aggravation of the problems to be expected from climate change.
This paper is an updated presentation of the Ramses project being currently developed at the University of Liège. The first section stresses the main objectives and gives a technical description of the general architecture of Ramses software. The second part describes the encoding procedures and reviews the current state of the annotation. In the third section, some changes brought about by the use of large-scale corpora are discussed from an epistemological viewpoint. The paper ends with the presentation of some new avenues for research that will ensue from the use of a complex multilevel corpus.
quoteSalute strives to make data of digital scholarly editions of letters (DSELs) accessible in a playful fashion by enabling users to integrate salutations from DSELs in their own email correspondence. The foundation of quoteSalute is a curated TEI-XML text corpus which has been created by extracting <salute>-tags from TEI-XML-encoded DSELs. For providing users with fitting salutations, we annotated the data regarding language, level of politeness and intended gender of sender and receiver.
When managing large quantities of data, it is a common solution to utilize a centralized data management software to forge a connection between metadata and the data objects themselves. In case of text-based objects without any attached metadata, it is easy for humans to contextualize these objects by recognizing patterns such as filenames, titles, authors etc. This task becomes a challenge when dealing with non-text-based objects like images in the cultural heritage domain. Without metadata or expert knowledge, it becomes difficult to estimate the creation date of a painting or tell the name of its painter. Thus, the ability to contextualize data depends on whether there is a working connection between the metadata store and the data object itself. This connection fails as soon as the file is moved on the file system without having these changes also applied in the corresponding
data base, or when the file is shared without a reference to its original location. This paper presents an approach to overcome that type of co-dependency by utilizing XMP to embed cultural heritage metadata directly into image files to ensure their location-independent long-term preservation. The “Corpus Vitrearum Medii Aevi” Germany (CVMA) project serves as an example use-case.
Agroecosystems are vital for supplying ecosystem services to human society, but most modern farming practices impact detrimentally on the environment. Public agricultural support policies have been critically important in influencing the transformation of the farm sectors; however, few of them have been dedicated to enhancing ecosystem services beyond agricultural commodities. The largest agricultural support system worldwide, the European Common Agricultural Policy (CAP), has now come to a critical point, as major decisions concerning its design and implementation after 2013 are about to be taken. The debate on this reform process presents a unique opportunity to trigger a transition from commodity-based subsidy policies to policies centered on efficient provision of ecosystem services from agricultural land. To prompt such discussion, we formulate key recommendations informed by a review of ecosystem services literature and address verifiable links to human well-being, non-market valuation for balanced services provision, treatment of ecosystem services bundles, site-specific and regionalized approaches, matching spatial scales for different ecosystem services, funding permanence for payment schemes, strong monitoring and adaptive approaches to tackling uncertainties, and coherent cross-sectoral policy design. If these issues were to be considered in formulating and implementing future CAP, it might become an exemplar for redirecting agricultural policies elsewhere in the world towards sustainability.
Most industrial countries have experienced a transformation of land use: from decreasing to expanding forest areas, the so-called forest transition. Outside closed forests, European rural landscapes exhibit a diversity of tree-based agricultural systems, but the question of whether this forest transition has also affected ‘trees outside forests’ has rarely been studied. The aim of this study is to analyze the spatial-temporal dynamics of farm trees and woodlands in an agricultural landscape in Eastern Germany from 1964 to 2008, based on aerial photographs and digital orthophotos. Taking a landscape ecological perspective, we quantify farm tree dynamics, disentangle processes of gain and loss in the socialist and post-socialist periods of Eastern Germany, and assess differences in ecosystem services provided by farm trees. A substantial increase of overall tree cover by 24.8% was observed for the selected time period, but trajectories have been disparate across different farm tree classes. The increase in tree cover was stronger in steep valleys than on hills and plateaus, indicating a significant interdependence between topography and trajectories of change. Patch numbers of farm trees did not increase, which suggests that the expansion of tree cover is mostly due to a spatial expansion of previously existing tree patches. Overall net gains in tree cover were rather similar during the socialist and post-socialist eras. The general increase in tree cover was accompanied by increases in agriculture-related ecosystem service provision, but the increase in pollination and pest control services was much lower than that in water purification services. These findings present the first empirical evidence from an industrialized country that there is also an ongoing ‘forest transition’ outside closed forests. Potential, partially counteracting drivers of change during the socialist and post-socialist periods have mainly been related to farm policies and the environmental consciousness of land users and society as a whole.
Eastern Mediterranean silvopastoral oak woodlands have been greatly damaged through forest conversion, illegal lumbering, overgrazing, and forest fires. The aim of this study was to assess land-use changes and the legacies that they have imprinted on the forest structure of Quercus macrolepis and accompanying Quercus pubescens and Quercus cerris woodlands on Lesvos Island, Greece. The size-structures of adult oak populations were analyzed as indicators of long-term oak regeneration, while short-term recruitment was determined by counting oak seedlings and saplings. The size-structure of the adult Q. macrolepis population was similar to the inverse J-shaped distribution typical for natural Mediterranean oak forests, indicating continuous recruitment with a constant mortality rate of mature individuals. Seedling and sapling densities were highly variable, but generally low in relation to adult oak densities. Recruitment of oak seedlings and saplings was positively related to determinants such as forest cover, adult oak density and basal area, woody plant richness, and litter cover. Both seedling and sapling occurrence was negatively associated with dung frequency, which suggests that sheep grazing imposes a barrier to oak recruitment. The study outlines a comprehensive land-use transition from the 1950s to the 1970s, during which a complex and multifunctional agrosilvopastoral land-use system was simplified to an intensive grazing system. The discrepancy between the successful long-term regeneration and the less successful short-term recruitment of oaks illustrates that intensified livestock grazing has been a major driver of vegetation change. Grazing impact is likely to interact with increasing drought conditions, which may trigger a negative feedback cycle that undermines the capacity of woodlands to sustain ecosystem services.
Numerous studies underline the importance of immaterial benefits provided by ecosystems and especially by cultural landscapes, which are shaped by intimate human–nature interactions. However, due to methodological challenges, cultural ecosystem services are rarely fully considered in ecosystem services assessments. This study performs a spatially explicit participatory mapping of the complete range of cultural ecosystem services and several disservices perceived by people living in a cultural landscape in Eastern Germany. The results stem from a combination of mapping exercises and structured interviews with 93 persons that were analyzed with statistical and GIS-based techniques. The results show that respondents relate diverse cultural services and multiple local-level sites to their individual well-being. Most importantly, aesthetic values, social relations and educational values were reported. Underlining the holistic nature of cultural ecosystem services, the results reveal bundles of services as well as particular patterns in the perception of these bundles for respondent groups with different socio-demographic backgrounds. Cultural services are not scattered randomly across a landscape, but rather follow specific patterns in terms of the intensity, richness and diversity of their provision. Resulting hotspots and coldspots of ecosystem services provision are related to landscape features and land cover forms. We conclude that, despite remaining methodological challenges, cultural services mapping assessments should be pushed ahead as indispensable elements in the management and protection of cultural landscapes. Spatially explicit information on cultural ecosystem services that incorporates the differentiated perceptions of local populations provides a rich basis for the development of sustainable land management strategies. These could realign the agendas of biodiversity conservation and cultural heritage preservation, thereby fostering multifunctionality.
The potential of agriculture, forestry, and other land uses to sequester carbon offers a powerful tool for controlling the global climate regime, but practices capable of creating “collateral” benefits for landscape conservation have thus far been disregarded. This paper calls for greater integration of scattered trees into agricultural landscapes, hypothesizing that agroforestry practices effectively store carbon and deliver other important ecosystem services as well. Several agroforests from the Upper Lusatia area in Eastern Germany have been selected for analysis. They cover relatively large areas of land (8.2%), even within this intensively used agricultural landscape, and their extent increased from 1964-2008 by 19.4%. Practices of conserving or promoting the six agroforest classes are compared with a catalogue of essential properties for becoming effective “carbon offset projects”. Criteria from mandatory and voluntary carbon markets for carbon sequestration are then applied (additionality, baselines, permanence, and carbon leakage). The study concludes that steps towards realization of “carbon sequestration projects” should include collecting empirical evidence regarding the carbon sequestration potential of temperate agroforestry systems, developing localised demonstration projects, and upscaling these projects to participate in established carbon markets.
This study explores the potential of historical maps to detect, measure and monitor changes of trees outside forests. The main goal is to assess local-level changes of scattered trees and orchards and their land-use determinants in two areas in Southern Germany between 1901/1905 and 2009. Firstly, overall landscape changes are recorded. Secondly, the spatial-temporal trajectories of scattered trees and their land-use determinants are identified. Thirdly, changes in quantity and fragmentation patterns of traditional orchards are analyzed in their relationship to overall land-cover change. The results confirm major losses in scattered trees, mainly due to urbanization, agricultural intensification, and land abandonment. They further reveal that, while orchards have persisted in total area, they have undergone critical changes towards a simplified landscape structure and loss of the traditional land-use mosaic, which is a characterizing feature of high nature value landscapes. Multi-temporal assessment showed that most trends have been continuous and did not change directions over time, but rather accelerated during periods of rapid change (most dramatically in the 1950-1990 period). The case of orchards and scattered trees illustrates a major problem of cultural landscapes in Europe: Semi-natural landscape features of high nature value are threatened by both intensification and abandonment of land uses. This makes their conservation a potentially costly enterprise, as both opportunity costs for lost alternative land uses and for conservation management costs arise.
Since humans are preferentially settling in flood plains they often influence freshwater systems intensely. The first signs of anthropogenic impacts on surface waters in the Berlin-Brandenburg region are approximately 3000 years old. Considering the multiple and intense human uses of surface waters in this region, we analysed when, how and to which extent regional rivers and streams became impacted by dams, water mills and fish weirs resulting in changes in morphology, hydrology and ecological functioning. We hypothesise that the development and growth of cities in this region necessitated (1) efficient navigability of rivers linking them, (2) efficient use of hydropower resources for mills, and (3) significant pollution of surface waters especially with the beginning of industrial development. We analyse these hypotheses by means of three regional examples and delineate the effects of human uses on selected surface water bodies. Understanding the effects of these historic modifications of surface water supports the identification of options for a sustainable use of surface waters that are currently still subjected to multiple uses but face a significant decrease in discharge due to climate change.
Early-career funding in German-African academic cooperation: achievements, challenges, perspectives
(2024)
This paper analyses experiences, challenges and potentials in German-African academic cooperation in the field of early-career funding considering the humanities and social sciences as well as natural sciences and medicine. It is based on a comprehensive overview of existing German funding formats and an exemplary survey of the experiences of African cooperation partners with these programmes. The authors propose the establishment of an interface between academic research, the practice of science funding, and African researchers. According to the authors, such a contact and information point would contribute to the improvement of German-African science cooperation and be an important element of Germany’s scientific diplomacy in the long term. This paper is the English translation of Denkanstoß 13 (2023): Early-Career-Förderung in der deutsch-afrikanischen Wissenschaftskooperation. Leistungen, Herausforderungen, Perspektiven. Berlin.
For decades, water resources have been used intensively for drinking water, industry, agriculture and energy production. This paper summarises the main anthropogenic influences on the water cycle in a Pleistocene landscape and associated geochemical reactions. The results allow the identification and description of the main hydraulic and geochemical processes that control water and solute fluxes in different hydrological compartments, in particular recharge and discharge regions. Under progressive climate change, this process-based knowledge should be used to adapt land and water management to minimise negative impacts on hydrological resources and stabilise the regional water balance in theBerlin-Brandenburg Pleistocene landscape. Based on these results, a risk assessment approach for validation of future management strategies under changing climate conditions is presented.
The future of biological diversity in a crowded world (Ernst Mayr Lecture on 29th October 2002)
(2006)
The Swedish Academy Dictionary (SAOB) is one of the big national dictionary projects started in the 19th century. SAOB is still in production – there are another two volumes out of 38 to printed before 2018. The structure inside the volumes is (of course) varied/varying. There are ten chief editors and five generations of editors involved in the project. In the 1980s the SAOB was OCR-scanned. The result was used for a webversion in the internet from 1997. The webversion is very frequently used but has a lot of shortcomings due to, among other things, a great typographic complexity and a scanning technology of the time. Now the editorial board is discussing the future: redigitalization (in China), updating of the webversion with new search tools, updating of the dictionary itself and some form of editing tool.
A reaction to the article „The Lost Archive“, The Wall Street Journal 12.1.2008, page 1 (US edition) http://online.wsj.com/article/SB120008793352784631.html The belief in the myth that old manuscripts should be mysterious and powerful is part and parcel of the age of Modernity. That such expectations were operative in the discussion on the Qumran fragments is still remembered, and more recently the Da Vinci Code, in itself a quite shallow story, sold extremely well. The fact that the Wall Street Journal placed an article on the “lost Bergsträsser-film archive” of Qur’anic manuscripts on its front page on 12th of January seems to be due to the myth of “textual wars” taking place in the world.
Emergence, analysis and optimization of structures - Concepts and strategies across disciplines
(2007)
The study of structures is a common concern of all scientific disciplines. The motivation as well as the methods of analysis, however, differ considerably. In engineering, the generation of artifacts, of infrastructures or technological processes are of primary interest. Frequently, the analysis aims at an optimization of the structures and the structure generating processes. Quite different is the study and explanation of existing structures in biology and the social sciences. Here the question of optimality does not present itself in an unambiguous manner. Generally, it must be questioned whether biological and social structures, although developing in an evolutionary way, can be considered as leading towards an a-priori defineable goal of optimality. The complex scenario of qualitative and quantitative modeling, and the goal-oriented and statistical approaches to understanding the meliorisation efforts in the various fields of the sciences and humanities define the scope of this book. Its intention is to create trans-disciplinary insights into methods to fecundate the custom disciplinary approaches.
Climate change is expected to increase water scarcity in northeast Germany. Land-use change is one of the options of mitigation that is intensely discussed in this region. This review aims at giving a compilation of existing data and modelling studies in order to investigate the potential and the limits of the land-use change approach.
My essay attends to a number of passages in Alexander von Humboldt’s "Personal Narrative" in which the Prussian explorer expresses anxiety about the apparent dangers posed by the overwhelmingly productive tropical landscapes he observes. In these passages, the excesses of an “exotic nature” threaten European identity and modes of civilization—and they trouble the accuracy of Humboldt’s own observational project. I also explore Humboldt’s related worry that South American vegetable (and visual) overload will exert a destabilizing effect on his aesthetic sensibility, disrupting his ability to represent the “New Continent” accurately in writing. Finally, I sketch the influence of Humboldt’s representations of tropical excess on nineteenth-century British cultural thought and literary practice. Studying the instabilities experienced by "Personal Narrative’s" expatriates and colonists promises to draw out important tensions latent in Humboldt’s treatment of tropical landscape and to illuminate broader epistemological and aesthetic shifts being worked out during the period.
Current financial and monetary difficulties in Europe are overshadowing the issue of a lack of common European identity. 200 years of nation states seem to have suppressed 1800 years of a history shaped by mutual enrichment in politics, science and the arts – a European cultural heritage. It is for the humanities and social sciences (SSH) to research, document and preserve this heritage, where the European science academies play a major role. However, a pan-European research programme on European cultural heritage and identity is still lacking, and, in comparison to the rest of the European SSH research landscape, the science academies are terra incognita. This book provides an analytical report of the first survey of basic research in the SSH conducted by the European scientific academies and related research organisations. It not only provides greatly needed information about this important area of the European research landscape, but also investigates the potential for a pan-European academies’ research programme in the SSH (including a corresponding digital infrastructure) that could strengthen the integration of European research into cultural heritage and identity. The main topic of this publication is the working practices of the projects surveyed with a focus on: o the science academies of Europe o research fields and topics o running times and funding o staff and early-stage researchers o research sites and access to research material o digital research practices o publication, dissemination and visibility o international collaboration o project evaluation
Berlin Text System 3.1 User Manual : Editorial Software of the Thesaurus Linguae Aegyptiae Project
(2018)
The Berlin Text System (BTS) Version 3.1 manual introduces a Java-based software designed for editing and annotating Ancient Egyptian texts. BTS integrates a CouchDB database and an Elastic search engine to support its main components: Text Editor, Lemma List, Thesaurus, and Abstract Text.
The Text Editor facilitates transliteration, translation, lemmatization, and annotations, allowing for detailed lexical and grammatical analysis. Hieroglyphic transcriptions can be entered via a specialized Hieroglyph Type Writer based on JSesh.
The Lemma List ist ready to contain pre-Coptic lemmata, divided into Hieroglyphic/Hieratic and Demotic scripts, providing comprehensive entries with passport data, transliterations, and translations.
The Thesaurus allows for metadata enrichment of texts with controlled vocabulary for consistent data management, supporting contextual analysis through structured metadata.
The manual covers BTS's user interface, including menu bar, toolbar, status bar, and workspace, divided into views for each main component. Features like Revision History for tracking and restoring versions, indexing, and search capabilities enhance user efficiency. BTS is a powerful tool for the study and preservation of Ancient Egyptian texts, integrating advanced database and search technologies with specialized textual analysis tools.
Even a reductionist attempt to define scholarship is clearly fraught with difficulty, but an idealised historical lexicographer-cum-scholar must obviously have – inter alia and at the very least – a profound linguistic and textual knowledge of the language being documented, an ability to understand texts in their historical context and to analyse the meaning or function of lexical items as used in context, an ability to synthesise the results through generalisation and abstraction and to formulate them in a way that is both accurate, i.e. reflects actual usage, and user- or reader-friendly, i.e. is comprehensible to the user/reader. S/he must have encyclopedic or world knowledge and literary skills in order to understand general content words and explain their meaning and their semantic shifts perhaps over many centuries, and technical expertise to understand specialist terms and define their use in specific contexts, again perhaps over time. In respect of etymology s/he must not only have knowledge of older stages of the language and an ability to reconstruct unattested forms, but also knowledge of the other languages that have impacted on the language being documented, or at least familiarity with the scholarly historical dictionaries of those languages. That is a tall order indeed, impossibly tall for any one person today given today‘s demands on and expectations of lexicographers. Teams which include specialists in different areas or at least have access to consultants in such areas alongside generalists are needed if scholarly standards are to be met. The standard of scholarship is primarily a factor of the number and range as well as the knowledge and experience of the lexicographers, as is in large measure the pace of production. In this regard, it cannot be emphasised enough that scholarly historical lexicography of high quality is and will remain very time consuming.
Even a reductionist attempt to define scholarship is clearly fraught with difficulty, but an idealised historical lexicographer-cum-scholar must obviously have – inter alia and at the very least – a profound linguistic and textual knowledge of the language being documented, an ability to understand texts in their historical context and to analyse the meaning or function of lexical items as used in context, an ability to synthesise the results through generalisation and abstraction and to formulate them in a way that is both accurate, i.e. reflects actual usage, and user- or reader-friendly, i.e. is comprehensible to the user/reader. S/he must have encyclopedic or world knowledge and literary skills in order to understand general content words and explain their meaning and their semantic shifts perhaps over many centuries, and technical expertise to understand specialist terms and define their use in specific contexts, again perhaps over time. In respect of etymology s/he must not only have knowledge of older stages of the language and an ability to reconstruct unattested forms, but also knowledge of the other languages that have impacted on the language being documented, or at least familiarity with the scholarly historical dictionaries of those languages. That is a tall order indeed, impossibly tall for any one person today given today‘s demands on and expectations of lexicographers. Teams which include specialists in different areas or at least have access to consultants in such areas alongside generalists are needed if scholarly standards are to be met. The standard of scholarship is primarily a factor of the number and range as well as the knowledge and experience of the lexicographers, as is in large measure the pace of production. In this regard, it cannot be emphasised enough that scholarly historical lexicography of high quality is and will remain very time consuming.
Die Erscheinungsform einer bestimmten Einzelsprache resultiert aus dem Nebeneinander und Zusammenwirken vertikaler und horizontaler Transmission von sprachlichen Merkmalen und umfasst demzufolge normalerweise neben Phänomenen, die über eine Kette früherer Sprechergenerationen ererbt wurden, auch solche, die aus anderen Sprachen entlehnt wurden. Deutliche Spuren einer komplexen Entstehungsgeschichte und der Interaktion verschiedener Sprachgemeinschaften lassen sich nicht erst im Altägyptischen oder gar erst in der Sprache des Neuen Reiches ausmachen, sondern bereits die frühesten schriftlichen Quellen aus der Zeit um 3000 v. Chr. erlauben – trotz ihrer Knappheit – überraschende Einblicke in die zeitgenössischen sprachlichen Verhältnisse. Bislang nur durch Sprachvergleich rekonstruierbare Entwicklungen sind nunmehr historisch nachweisbar, und das phonologische System einer dem Altägyptischen vorausgehenden und erheblich von ihm abweichenden Sprachstufe wird greifbar. Da das Voraltägyptische ein für eine afroasiatische Sprache eher untypisches Konsonanteninventar besitzt und sich zudem lexikalische Übereinstimmungen (nicht-genetischer Natur) mit indoeuropäischen Sprachen abzeichnen, erscheinen fundierte Hypothesen über die Herausbildung des Ägyptischen nicht länger unmöglich. Damit wäre das Ägyptische nicht nur die am längsten bezeugte Einzelsprache der Menschheitsgeschichte, sondern wohl auch die einzige, die von ihrer Entstehung bis zu ihrem Aussterben schriftlich dokumentiert ist.
Virtually all conventional text-based natural language processing techniques - from traditional information retrieval systems to full-fledged parsers - require reference to a fixed lexicon accessed by surface form, typically trained from or constructed for synchronic input text adhering strictly to contemporary orthographic conventions. Unconventional input such as historical text which violates these conventions therefore presents difficulties for any such system due to lexical variants present in the input but missing from the application lexicon. To facilitate the extension of synchronically-oriented natural language processing techniques to historical text while minimizing the need for specialized lexical resources, one may first attempt an automatic canonicalization of the input text. This paper provides an informal overview of the various canonicalization techniques currently employed by the Deutsches Textarchiv project at the Berlin-Brandenburg Academy of Sciences and Humanities to prepare a corpus of historical German text for part-of-speech tagging, lemmatization, and integration into a robust online information retrieval system.
Introduction
(2019)
Global change is posing a major challenge to existing forms of natural resource use, socio-economic development and institutional regulation. Although trends such as climate change, socio-economic transformation and institutional change are global in their scope, they have very specific regional outcomes. Regionally distinct coping strategies are required which take into account both the diversity of regional impacts of global change and the local contexts of appropriate responses. This paper explores the impacts of global change on the management of water infrastructure systems in the Berlin-Brandenburg region in terms of three concurrent and overlapping challenges: climate change, socio-economic change and institutional change. It subsequently examines how regional actors in the water sector are addressing these three dimensions of global change.
Over millennia human well-being has benefited from ecosystems, not only through tangible goods, but also through intangible assets known as cultural ecosystem services. Despite growing research over the last decade, cultural services assessment still remains arbitrary and is largely limited to marketable services such as tourism. Evident difficulties in standardizing definitions and measurements have challenged cultural services accounting in decision making processes. However, the imminent formation of the Intergovernmental Platform on Biodiversity and Ecosystem Services offers an opportunity to counterbalance this misrepresentation by establishing a scientific basis for consistently assessing cultural services. In that regard, the current review intends to facilitate discussion investigating the current state of cultural services accounting by offering an appraisal of existing evidence regarding cultural services indicator quality. The current review builds on scientifically recognized frameworks to develop a holistic understanding of how cultural services indicators are conceived within ecosystem services research. Among the measures found, benefit indicators were most frequently used for assessing inspirational, educational and recreational services. A broad variety of methods for accounting cultural services was found, mainly due to the varied aims of the studies. Most of the cultural services indicators were deficient concerning their clarity of definitions, purposes and understanding of the processes to be measured and referring only marginally to tradeoffs and bundles with other services. Only 17% performed multitemporal assessments and 23% used spatially explicit information. It seems that cultural services indicators quality could be greatly enhanced by investing more effort towards involving relevant stakeholders in conceptualization and communication phases, using participatory mapping tools to enhance visibility.
From exclusion to inclusion : improving clinical research in vulnerable populations ; memorandum
(2014)
Therapeutic care for vulnerable populations – meaning patient groups such as underage children and the mentally ill that have limited or no capacity for giving informed consent – is severely lacking. Thus, for example, a great portion of pharmaceuticals used in the treatment of children and youth have not been specifically designed for these groups, which often results in side effects that are disproportionate to those associated with such medicines when used by adults. Moreover, vulnerable populations are at times faced with having no therapies at all for some of their ailments, such that children and dementia sufferers, for example, are often considered to be “therapeutic orphans”. It is therefore urgent that clinical research be carried out among vulnerable populations in order to improve their therapeutic possibilities. The Clinical Research on Vulnerable Populations Research Group – a cooperative effort between the Berlin-Brandenburg Academy of Sciences and Humanities (Berlin, Germany) and the European Academy of Technology Assessment (Bad Neuenahr, Germany) – has set itself the task of analyzing the state of clinical research on vulnerable populations so as to be able to develop suggestions for improving future research of this kind. The results of this work are presented in the following memorandum, which seeks to portray the state-of-the-art in this domain while also assessing the strengths and weaknesses of contemporary ethical and medical perspectives related to it. The memorandum is primarily oriented towards those in the relevant scientific disciplines who can benefit from obtaining an informed consensus regarding the current state of the discussions taking place around this topic.
Among mass digitization methods, double-keying is considered to be the one with the lowest error rate. This method requires two independent transcriptions of a text by two different operators. It is particularly well suited to historical texts, which often exhibit deficiencies like poor master copies or other difficulties such as spelling variation or complex text structures. Providers of data entry services using the double-keying method generally advertise very high accuracy rates (around 99.95% to 99.98%). These advertised percentages are generally estimated on the basis of small samples, and little if anything is said about either the actual amount of text or the text genres which have been proofread, about error types, proofreaders, etc. In order to obtain significant data on this problem it is necessary to analyze a large amount of text representing a balanced sample of different text types, to distinguish the structural XML/TEI level from the typographical level, and to differentiate between various types of errors which may originate from different sources and may not be equally severe. This paper presents an extensive and complex approach to the analysis and correction of double-keying errors which has been applied by the DFG-funded project “Deutsches Textarchiv” (German Text Archive, hereafter DTA) in order to evaluate and preferably to increase the transcription and annotation accuracy of double-keyed DTA texts. Statistical analyses of the results gained from proofreading a large quantity of text are presented, which verify the common accuracy rates for the double-keying method.
The FEW is a huge dictionary when we consider the sheer mass of data (25 volumes, 16000 pages) and its exhaustive aims. It has indeed the purpose of registering and etymologizing the whole lexicon, not only of French, but also of earlier stages of the language and of Occitan; of every Gallo-romance dialect; of every technical or professional genre; of every language register, including slang. Summing up, the FEW aims to include and describe every single lexical unit which exists or has existed in the territory of ancient Gaul. The sheer size of this undertaking means two things, which directly influence the digitalisation of the dictionary: Firstly, there is a a huge amount of data; secondly, the presentation and organization of the data is exceedingly complex. The reasons for digitalising the FEW are the easy searches for units, and the carrying out of searches using criteria that are not possible to use with the printed version. However, the fulfillment of these purposes includes some risks, and potentially the cutting of some corners, especially the temptation of renouncing reading.
An der Sprache des Rechts wird Kritik geübt, seit die Aufklärung die Verständlichkeit der Gesetze zu ihrem Anliegen gemacht hat. Mit den großen Kodifikationen des Rechts im ausgehenden 19. Jahrhundert hat die Kritik am angeblich schlechten, unverständlichen Juristendeutsch eine besondere demokratietheoretische Legitimation bekommen. Diese Sprachkritik sucht seit den siebziger Jahren vermehrt bei der Linguistik Rat, wie denn eine bessere Allgemeinverständlichkeit von Rechtstexten verwirklicht werden könnte. Der Band versammelt systematisch aufeinander bezogene Beiträge ausgewiesener Linguisten, Juristen und Schriftsteller zur Problematik des Verständnisses juristischer Sprache, zur Methodik empirischer Verständlichkeitsmessung und zu den Möglichkeiten transdisziplinärer Kooperation zwischen Rechts- und Sprachwissenschaftlern.
The article summarizes the contents and the structurtal premises of the “Thesaurus Indogermanischer Text- und Sprachmaterialien” (TITUS), focussing on search functions and facilities and questions of the encoding of ancient languages written in various scripts. Examples are taken from Tocharian, Greek, Vedic Sanskrit, and other ancient Indo-European languages covered by TITUS.
Upon separation of the protein from the nucleic acid component of tobacco mosaic virus by phenol, using a fast and gentle procedure, the nucleic acid is infective in assays on tobacco leaves. A series of qualitative and quantitative control experiments demonstrates that the biological activity cannot depend on residual proteins in the preparation, but is a property of isolated nucleic acid which is thus the genetic material of the virus.
The generation of viral mutants in vitro was demonstrated by treatment of the isolated RNA of Tobacco Mosaic Virus by nitrous acid. This agent causes deaminations converting cytosine into uracil, and adenine into hypoxanthine. Our assay for mutagenesis was the production of local lesions on a tobacco variety on which the untreated strain produces systemic infections only. A variety of different mutants are generated in this way. Quantitative analysis of the kinetics of mutagenesis leads to the conclusion that alteration of a single out of the 6000 nucleotides of the viral RNA is sufficient for causing a mutation.
The paper addresses the formation of striking patterns within originally near-homogenous tissue, the process prototypical for embryology, and represented in particularly puristic form by cut sections of hydra regenerating a complete animal with head and foot. Essential requirements are autocatalytic, self-enhancing activation, combined with inhibitory or depletion effects of wider range - “lateral inhibition”. Not only de-novo-pattern formation, but also well known, striking features of developmental regulation such as induction, inhibition, and proportion regulation can be explained on this basis. The theory provides a mathematical recipe for the construction of molecular models with criteria for the necessary non-linear interactions. It has since been widely applied to different developmental processes.
Aggregates of previously isolated cells of Hydra are capable, under suitable solvant conditions, of regeneration forming complete animals. In a first stage, ecto- and endodermal cells sort out, producing the bilayered hollow structure characteristic of Hydra tissue; thereafter, heads are formed (even if the original cell preparation contained no head cells), eventually leading to the separation of normal animals with head, body column and foot. Hydra appears to be the highest type of organism that allows for regeneration of the entire structure from random cell aggregates. The system is particularly useful for studying cell interactions, tissue polarity, pattern formation, and cell differentiation.
Physical principles underlying biological pattern formation are discussed. In particular, the combination of local self-enhancement and long-range (“lateral”) inhibition (Gierer and Meinhardt, 1972) accounts for de-novo pattern formation, and for striking features of developmental regulation such as induction, spacing and proportion regulation of centers of activation in tissues and cells. Part I explains physical principles of spatial organisation in biological development. Part II demonstrates in mathematical terms that and how short-range activation and long-range inhibition are conditions for the generation of spatial concentration patterns. The conditions can be expressed in terms of ranges, rates and orders of reactions. These conditions, in turn, can also be derived by analysis of dynamic instabilities by means of Fourier waves, showing the neither obvious nor trivial relation between the latter approach and the theory based primarily on autocatalysis and lateral inhibition.
Validity of physical laws for any aspect of brain activity and strict correlation of mental to physical states of the brain do not imply, with logical necessity, that a complete algorithmic theory of the mind-body relation is possible. A limit of decodability may be imposed by the finite number of possible analytical operations which is rooted in the finiteness of the world. It is considered as a fundamental intrinsic limitation of the scientific approach comparable to quantum indeterminacy and the theorems of logical undecidability. An analysis of these limits, applied to dispositions of future behaviour, suggests that limits of decodability of the psycho-physic relation may actually exist with respect to brain states with self-referential aspects, as they are involved in mental processes. Limits for an algorithmic theory of the mind-body problem suggested by this study are formally similar to other intrinsic limits of the scientific method such as quantum indeterminacy and mathematical undecidability which are also related to self-referential operations. At the metatheoretical level, hard sciences, despite their reliability, universality and objectivity, depend on metatheoretical presuppositions which allow for multiple philosophical interpretations.
Aside from the increasing, impressive evidence on chemical identification of graded molecules involved, it is the capability of axons for approaching the target position from different aspects in a two-dimensional field which is per se a strong indication for the involvement of gradients. Targeting requires, in the target field, counter-graded effects, either by antagonistic gradients, or by a single gradient in each dimension exerting attractive effects at low, reverting to inhibitory (repulsive) effects at high concentrations. A further requirement for mapping is the modulation of the counter-graded effects by components of the growth cone itself which depends on the origin of the corresponding axon.Transduction and processing of graded signals in the navigating growth cones are proposed to be strongly enhanced by intra-growth-cone pattern formation. The concept also encompasses regulatory and branching processes including the formation of the terminal arbors.
Modern science, based on the laws of physics, claims validity for all events in space and time. However, it also reveals its own limitations, such as the indeterminacy of quantum physics, the limits of decidability, and, presumably, limits of decodability of the mind-brain relationship. At the philosophical level, these intrinsic limitations allow for different interpretations of the relation between human cognition and the natural order. In particular, modern science may be logically consistent with religious as well as agnostic views of humans and the universe. These points are exemplified through the transcript of a discussion between Kurt Gödel and Rudolf Carnap that took place in 1940. Gödel, discoverer of mathematical undecidability, took a proreligious view; Carnap, one of the founders of analytical philosophy, an antireligious view. By the time of the discussion, Carnap had liberalized his ideas on theoretical concepts of science: he believed that observational terms do not suffice for an exhaustive definition of theoretical concepts. Then, responded Gödel, one should formulate a theory or metatheory that is consistent with scientific rationality, yet also encompasses theology. Carnap considered such theories unproductive. The controversy remained unresolved, but its emphasis shifted from rationality to wisdom, not only in the Gödel-Carnap discussion but also in our time.
The development of modern science has depended strongly on specific features of the cultures involved; however, its results are widely and transculturally accepted and applied. The science and technology of electricity, for example, emerged as a specific product of post-Renaissance Europe, rooted in the Greek philosophical tradition that encourages explanations of nature in theoretical terms. It did not evolve in China presumably because such encouragement was missing. The transcultural acceptance of modern science and technology is postulated to be due, in part, to the common biological dispositions underlying human cognition, with generalizable capabilities of abstract, symbolic and strategic thought. These faculties of the human mind are main prerequisites for dynamic cultural development and differentiation. They appear to have evolved up to a stage of hunters and gatherers perhaps some 100 000 years ago. However, the extent of the correspondence between some constructions of the human mind and the order of nature, as revealed by science, is a late insight of the last two centuries. Unless we subscribe to extreme forms of constructivism or historical relativism, we may take the success and the formal structure of science as indications of a close, intrinsic relation between the physical and the mental, between the order of nature and the structure of human cognition. At the metatheoretical level, however, modern science is consistent with philosophical and cultural diversity.
The topic of this article is the relation between bottom-up and top-down, reductionist and “holistic” approaches to the solution of basic biological problems. While there is no doubt that the laws of physics apply to all events in space and time, including the domains of life, understanding biology depends not only on elucidating the role of the molecules involved, but, to an increasing extent, on systems theoretical approaches in diverse fields of the life sciences. Examples discussed in this article are the generation of spatial patterns in development by the interplay of autocatalysis and lateral inhibition; the evolution of integrating capabilities of the human brain, such as cognition-based empathy; and both neurobiological and epistemological aspects of scientific theories of consciousness and the mind.
Biological evolution and technological innovation, while differing in many respects, also share common features. In particular, the implementation of a new technology in the market is analogous to the spreading of a new genetic trait in a population. Technological innovation may occur either through the accumulation of quantitative changes, as in the development of the ocean clipper, or it may be initiated by a new combination of features or subsystems, as in the case of steamships. Other examples of the latter type are electric networks that combine the generation, distribution, and use of electricity, and containerized transportation that combines standardized containers, logistics, and ships. Biological evolution proceeds, phenotypically, in many small steps, but at the genetic level novel features may arise not only through the accumulation of many small, common mutational changes, but also when distinct, relatively rare genetic changes are followed by many further mutations. New evolutionary directions may be initiated by, in particular, some rare combinations of regulatory sections within the genome. The combinatorial type of mechanism may not be a logical prerequisite for biological innovation, but it can be efficient, especially when novel features arise out of already highly developed systems. Such is the case with the evolution of general, widely applicable capabilities of the human brain. Hypothetical examples include the evolution of strategic thought, which encompasses multiple self-representations, cognition-based empathy, meta-levels of abstraction, and symbolic language. These capabilities of biologically modern man may have been initiated, perhaps some 150 000 years ago, by one or few accidental but distinct combinations of modules and subroutines of gene regulation which are involved in the generation of the neural network in the cerebral cortex. This hypothesis concurs with current insights into the molecular biology of the combinatorial and hierarchical facets of gene regulation that underlie brain development. A theory of innovation encompassing technological as well as biological development cannot per se dictate alternative explanations of biological evolution, but it may help in adding weight and directing attention to notions outside the mainstream, such as the hypothesis that few distinct genetic changes were crucial for the evolution of modern man.
Within the sedimentation diagram of infective RNA preparations isolated from Tobacco Mosaic Virus, undegraded molecules form a sharp peak with a molecular weight corresponding to the total RNA content of the virus particle. Degradation kinetics by ribonuclease is of the linear, single-target type, indicating that the RNA is single-stranded. The intact RNA of a virus particle thus forms one big single-stranded molecule. Quantitative evaluation of the effect degradation by RNA-ase on the infectivity of the RNA shows that the integrity of the entire molecule is required for its biological activity.
Ancient Greek philosophers were the first to postulate the possibility of explaining nature in theoretical terms and to initiate attempts at this. With the rise of monotheistic religions of revelation claiming supremacy over human reason and envisaging a new world to come, studies of the natural order of the transient world were widely considered undesirable. Later, in the Middle Ages, the desire for human understanding of nature in terms of reason was revived. This article is concerned with the fundamental reversal of attitudes, from “undesirable” to “desirable”, that eventually led into the foundations of modern science. One of the earliest, most ingenious and most interesting personalities involved was Eriugena, a theologian at the Court of Charles the Bald in the 9th century. Though understanding what we call nature is only one of the several aspects of his theological work, his line of thought implies a turn into a pro-scientific direction: the natural order is to be understood in abstract terms of ‘primordial causes’; understanding nature is considered to be the will of God; man encompasses the whole of creation in a physical as well as a mental sense. Basically similar ideas on the reconciliation of scientific rationality and monotheistic religions of revelation were conceived, independently and nearly simultaneously, by the Arab philosopher al-Kindi in Bagdad. Eriugena was more outspoken in his claim that reason is superior to authority. This claim is implicit in the thought of Nicholas of Cusa with his emphasis on human mental creativity as the image of God’s creativity; and it is the keynote of Galileo’s ‘Letter to the Grand Duchess Christina’ some 800 years later, the manifesto expressing basic attitudes of modern science. This article in English is based on the monography (in German): A. Gierer “Eriugena, al-Kindi, Nikolaus von Kues - Protagonisten einer wissenschaftsfreundlichen Wende im philosophischen und theologischen Denken”, Acta Historica Leopoldina 29 (1999), Barth Verlag in MVH Verlage Heidelberg, ISBN: 3-335-00652-6
Applying mild methods of preparation, part of the ribosomes of rabbit reticulocytes are found in aggregates (later called polyribosomes) of up to six ribosomal units. Upon treatment with RNA-ase, they desintegrate into single ribosomes. The fast-sedimenting aggregates are found to be more active in protein synthesis in terms of incorporation of radioactive amino acids, whereas the single ribosomes are more receptive to stimulation by the artificial messenger RNA poly-U. The findings indicate that the linkage of ribosomes into aggregates is due to the messenger RNA. They support a tape-reading mechanism of protein synthesis whereby growth of the peptide chain is accompanied by shifting the active site of the ribosome from one coding group of nucleotides of the messenger RNA to the next.
This is the invited evening lecture of the biannual workshop on hydroid development of 1999. Its topic is the role of hydra as a rather puristic model for the de-novo generation of spatial patterns in development, and our work in this field. Emphasis is placed not only on experimental studies, but also on theoretical analysis, because the understanding of spatial order requires a systems approach involving the combination of knowledge on molecules, cells and tissues with mathematical analysis, laws and facts.
Understanding cooperative human behaviour depends on insights into the biological basis of human altruism, as well as into socio-cultural development. In terms of evolutionary theory, kinship and reciprocity are well established as underlying cooperativeness. Reasons will be given suggesting an additional source, the capability of a cognition-based empathy that may have evolved as a by-product of strategic thought. An assessment of the range, the intrinsic limitations, and the conditions for activation of human cooperativeness would profit from a systems approach combining biological and socio-cultural aspects. However, this is not yet the prevailing attitude among contemporary social and biological scientists who often hold prejudiced views of each other's notions. It is therefore worth noticing that the desirable integration of aspects has already been attempted, in remarkable and encouraging ways, in the history of thought on human nature. I will exemplify this with the ideas of the fourteenth century Arab-Muslim historian Ibn Khaldun. He set out to explicate human cooperativeness - "asabiyah" - as having a biological basis in common descent, but being extendable far beyond within social systems, though in a relatively unstable and attenuated fashion. He combined psychological and material factors in a dynamical theory of the rise and decline of political rulership, and related general social phenomena to basic features of human behaviour influenced by kinship, expectation of reciprocity, and empathic emotions.
Full applicability of physics to human biology does not necessarily imply that one can uncover a comprehensive, algorithmic correlation between physical brain states and corresponding mental states. The argument takes into account that information processing is finite in principle in a finite world. Presumbly the brain-mind-relation cannot be resolved in all essential aspects, particularly when high degrees of abstraction or self-analytical processes are involved. Our conjecture plausibly unifies the universal validity of physics and a logical limitation of human thought, and it does not regard consciousness -the most basic human experience - as a marginal phenomenon. ++++ RATIO appeared up to 1987 in both a German and an English version. The German title of this article: Alfred Gierer, Der physikalische Grundlegungsversuch in der Biologie und das psychophysische Problem. RATIO XII, Heft 1, 1970, S. 40-54.
Modern brain research related to consciousness has resulted in many interesting in- sights, for example into the neurobiological basis of attention and of language. In biological terms, human consciousness appears as a system’s feature of our brain, with neural processes strictly following the laws of physics. This does not necessarily imply, however, that there can be a general and comprehensive scientific theory of consciousness. Predictions of the extent to which such a theory may become possi- ble vary widely in the scientific community. There are reasons - not only practical but also epistemological - why the brain-mind relation may not be fully decodable by finite procedures. In particular, analogies with mathematical theorems of un- decidability suggest that self-referential features of consciousness, such as multiple self-representations like those involved in strategic thought, may not be fully resolv- able by brain analysis. Assuming such limitations exist, this implies that ob jective analysis cannot exhaust sub jective experience in principle. A person’s consciousness and will are accessible to external observation only within limits. In some respects, we do not even learn to know ourselves except by our actions. It thus appears that a scientific look at consciousness and the human mind, combining universal physi- calism with epistemological scepticism, is not inconsistent with certain concepts of sub jectivity that are current in the humanities, despite all the differences in the style and terminology of discourse.
Socioeconomic inequalities are functions not only of intrinsic differences between persons or groups, but also of the dynamics of their interactions. Inequalities can arise and become stabilized if there are advantages (such as generalized wealth including “human capital”) which are self-enhancing, whereas depletion of limiting resources is widely distributed. A recent theory of biological pattern formation has been generalized, adapted and applied to deal with this process. Applications include models for the non-Gaussian distribution of personal income and wealth, for overall economic growth in relation to inequalities and for effects of uncoupling strategies between developing and developed countries. Note added after publication: The equations (14) for the model of the income distribution, with its characteristic non-Gaussian extension towards higher incomes (fig.4), are closely related to the Fokker-Planck equation that is widely applied in many fields of physics.
The introductory personal remarks refer to my motivations for choosing research projects, and for moving from physics to molecular biology and then to development, with Hydra as a model system. Historically, Trembley’s discovery of Hydra regeneration in 1744 was the begin¬ning of developmental biology as we understand it, with passionate debates about preformation versus de novo generation, mechanisms versus organisms. In fact, seemingly conflicting bottom-up and top-down concepts are both required in combination to understand development. In modern terms, this means analysing the molecules involved, as well as searching for physical principles underlying development within systems of molecules, cells and tissues. During the last decade, molecular biology has provided surprising and impressive evidence that the same types of mol¬ecules and molecular systems are involved in pattern formation in a wide range of organisms, including coelenterates like Hydra, and thus appear to have been “invented” early in evolution. Likewise, the features of certain systems, especially those of developmental regulation, are found in many different organisms. This includes the generation of spatial structures by the interplay of self-enhancing activation and “lateral” inhibitory effects of wider range, which is a main topic of my essay. Hydra regeneration is a particularly clear model for the formation of defined patterns within initially near-uniform tissues. In conclusion, this essay emphasizes the analysis of development in terms of physical laws, including the application of mathematics, and insists that Hydra was, and will continue to be, a rewarding model for understanding general features of embryogenesis and regeneration.